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Prospective Associations between Cumulative Average Intake of Flavonoids and Hypertension Risk in the CArdioVascular Disease Association Study (CAVAS)

 Ji-Sook Kong  ;  Yu-Mi Kim  ;  Hye-Won Woo  ;  Min-Ho Shin  ;  Sang-Baek Koh  ;  Hyeon-Chang Kim  ;  Jin-Ho Shin  ;  Mi-Kyung Kim 
 NUTRIENTS, Vol.15(5) : 1186, 2023-03 
Journal Title
Issue Date
Adult ; Anthocyanins ; Cardiovascular Diseases* ; Diet ; Flavonoids ; Humans ; Hypertension* ; Male ; Middle Aged ; Obesity ; Overweight ; Proanthocyanidins* ; Prospective Studies ; Risk Factors
CAVAS ; Republic of Korea ; cohort ; flavonoids ; hypertension ; obesity ; prospective ; subclasses
In this study, we aimed to investigate the prospective associations and their shapes between the dietary intake of total flavonoids and their seven subclasses and hypertension risk in a prospective cohort, the KoGES_CArdioVascular disease Association Study (CAVAS), and to consider obesity status as an additional factor. A total of 10,325 adults aged 40 years and older were enrolled at baseline, and 2159 patients were newly diagnosed with hypertension during a median follow-up of 4.95 years. Cumulative dietary intake was estimated using a repeated food frequency questionnaire. Incidence rate ratios (IRRs) with 95% confidence intervals (CIs) were estimated using modified Poisson models with a robust error estimator. We observed nonlinear inverse associations between total and seven subclasses of flavonoids and hypertension risk, although there was no significant association between total flavonoids and flavones with hypertension risk in the highest quartile. For men, these inverse associations tended to be pronounced in the high BMI group, particularly for anthocyanins and proanthocyanidins [IRR (95% CI) in overweight/obese men: 0.53 (0.42–0.67) for anthocyanins; 0.55 (0.42–0.71) for proanthocyanidins]. Our results suggested that consumption of dietary flavonoids may not be dose-responsive but is inversely associated with hypertension risk, particularly among overweight/obese men. © 2023 by the authors.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
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