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The Relationship between Delirium and Statin Use According to Disease Severity in Patients in the Intensive Care Unit

Authors
 Jun Yong An  ;  Jin Young Park  ;  Jaehwa Cho  ;  Hesun Erin Kim  ;  Jaesub Park  ;  Jooyoung Oh 
Citation
 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, Vol.21(1) : 179-187, 2023-02 
Journal Title
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
ISSN
 1738-1088 
Issue Date
2023-02
Keywords
APACHE II score ; Delirium ; Disease severity ; Intensive care unit ; Neuroinflammation ; Statin
Abstract
Objective: The aim of this study was to investigate the association between the use of statins and the occurrence of delirium in a large cohort of patients in the intensive care unit (ICU), considering disease severity and statin properties. Methods: We obtained clinical and demographical information from 3,604 patients admitted to the ICU from January 2013 to April 2020. This included information on daily statin use and delirium state, as assessed by the Confusion Assessment Method for ICU. We used inverse probability of treatment weighting and categorized the patients into four groups based on the Acute Physiology and Chronic Health Evaluation II score (group 1: 0−10 - mild; group 2: 11−20 - mild to moderate; group 3: 21−30 - moderate to severe; group 4: > 30 - severe). We analyzed the association between the use of statin and the occurrence of delirium in each group, while taking into account the properties of statins. Results: Comparisons between statin and non-statin patient groups revealed that only in group 2, patients who were administered statin showed significantly higher occurrence of delirium (p = 0.004, odds ratio [OR] = 1.58) compared to the patients who did not receive statin. Regardless of whether statins were lipophilic (p = 0.036, OR = 1.47) or hydrophilic (p = 0.032, OR = 1.84), the occurrence of delirium was higher only in patients from group 2. Conclusion: The use of statins may be associated with the increases in the risk of delirium occurrence in patients with mild to moderate disease severity, irrespective of statin properties.
Files in This Item:
T202301956.pdf Download
DOI
10.9758/cpn.2023.21.1.179
Appears in Collections:
6. Others (기타) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hesun Erin(김희선)
Park, Jaesub(박재섭)
Park, Jin Young(박진영)
Oh, Jooyoung(오주영) ORCID logo https://orcid.org/0000-0001-6721-399X
Cho, Jaehwa(조재화) ORCID logo https://orcid.org/0000-0002-3432-3997
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194091
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