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Cerium oxide nanozymes confer a cytoprotective and bio-friendly surface micro-environment to methacrylate based oro-facial prostheses

 Jie Jin  ;  Utkarsh Mangal  ;  Ji-Young Seo  ;  Ji-Yeong Kim  ;  Jeong-Hyun Ryu  ;  Young-Hee Lee  ;  Cerjay Lugtu  ;  Geelsu Hwang  ;  Jung-Yul Cha  ;  Kee-Joon Lee  ;  Hyung-Seog Yu  ;  Kwang-Mahn Kim  ;  Sungil Jang  ;  Jae-Sung Kwon  ;  Sung-Hwan Choi 
 BIOMATERIALS, Vol.296 : 122063, 2023-05 
Journal Title
Issue Date
Cerium* / pharmacology ; Humans ; Methacrylates ; Polymethyl Methacrylate* ; Prostheses and Implants
Bioactive ; Biofilm resistance ; Ceria nanoparticle ; Poly-(methyl methacrylate) ; nanozyme
Poly-(methyl methacrylate) (PMMA) is the preferred biomaterial for orofacial prostheses used for the rehabilitation of naso-palatal defects. However, conventional PMMA has limitations determined by the complexity of the local microbiota and the friability of oral mucosa adjacent to these defects. Our purpose was to develop a new type of PMMA, i-PMMA, with good biocompatibility and better biological effects such as higher resistance to microbial adhesion of multiple species and enhanced antioxidant effect. The addition of cerium oxide nanoparticles to PMMA using a mesoporous nano-silica carrier and polybetaine conditioning, resulted in an increased release of cerium ions and enzyme mimetic activity, without tangible loss of mechanical properties. Ex vivo experiments confirmed these observations. In stressed human gingival fibroblasts, i-PMMA reduced the levels of reactive oxygen species and increased the expression of homeostasis-related proteins (PPARg, ATG5, LCI/III). Furthermore, i-PMMA increased the levels of expression of superoxide dismutase and mitogen-activated protein kinases (ERK and Akt), and cellular migration. Lastly, we demonstrated the biosafety of i-PMMA using two in vivo models: skin sensitization assay and oral mucosa irritation test, respectively. Therefore, i-PMMA offers a cytoprotective interface that prevents microbial adhesion and attenuates oxidative stress, thus supporting physiological recovery of the oral mucosa. © 2023 Elsevier Ltd
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Kim, Ji Young(김지영)
Mangal, Utkarsh(만갈웃커시)
Yu, Hyung Seog(유형석) ORCID logo https://orcid.org/0000-0002-1275-5078
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Cha, Jung Yul(차정열)
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
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