Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene

Jeon, Saebom; Kim, Hyoeun; Chun, Kyeong-Hyeon; Oh, Jae Won; Kwon, Chulan; Choi, Hyo-Kyoung; Kim, Sang woo; Kim, Hyoung Pyo; Kim, In-Cheol; Yoo, Jung-Yoon; Park, Sahng Wook; Kang, Seok Min; Lee , Seung hyun

doi:10.1016/j.scr.2023.103048

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Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene

Authors: Jeon, Saebom ; Kim, Hyoeun ; Chun, Kyeong-Hyeon ; Oh, Jae Won ; Kwon, Chulan ; Choi, Hyo-Kyoung ; Kim, Sang woo ; Kim, Hyoung Pyo ; Kim, In-Cheol ; Yoo, Jung-Yoon ; Park, Sahng Wook ; Kang, Seok Min ; Lee , Seung hyun

Citation: Stem Cell Research, Vol.67, 2023-03

Article Number: 103048

Journal Title: STEM CELL RESEARCH

ISSN: 1873-5061

Issue Date: 2023-03

Abstract: Cardiac muscle troponin T protein binds to tropomyosin and regulates the calcium-dependent actin-myosin interaction on thin filaments in cardiomyocytes. Recent genetic studies have revealed that TNNT2 mutations are strongly linked to dilated cardiomyopathy (DCM). In this study, we generated YCMi007-A, a human induced pluripotent stem cell (hiPSC) line from a DCM patient with a p. Arg205Trp mutation in the TNNT2 gene. The YCMi007-A cells show high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Thus, YCMi007-A-an established iPSC-could be useful for the investigation of DCM.

DOI: 10.1016/j.scr.2023.103048

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers

Yonsei Authors: Kang, Seok Min(강석민) https://orcid.org/0000-0001-9856-9227
Kim, Sangwoo(김상우) https://orcid.org/0000-0001-5356-0827
Kim, Hyoung Pyo(김형표) https://orcid.org/0000-0003-1441-8822
Kim, Hyo Eun(김효은)
Park, Sahng Wook(박상욱) https://orcid.org/0000-0002-9594-7074
Oh, Jae Won(오재원) https://orcid.org/0000-0002-4585-1488
Lee, Seung Hyun(이승현)
Jeon, Sae-Bom(전새봄) https://orcid.org/0000-0002-0206-5532

URI: https://ir.ymlib.yonsei.ac.kr/handle/22282913/194050

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