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RNA Metabolism in T Lymphocytes

Authors
 Jin Ouk Choi  ;  Jeong Hyeon Ham  ;  Soo Seok Hwang 
Citation
 IMMUNE NETWORK, Vol.22(5) : e39, 2022-10 
Journal Title
IMMUNE NETWORK
ISSN
 1598-2629 
Issue Date
2022-10
Keywords
Cellular ; Immunity ; RNA ; RNA metabolism ; T-lymphocytes
Abstract
RNA metabolism plays a central role in regulating of T cell-mediated immunity. RNA processing, modifications, and regulations of RNA decay influence the tight and rapid regulation of gene expression during T cell phase transition. Thymic selection, quiescence maintenance, activation, differentiation, and effector functions of T cells are dependent on selective RNA modulations. Recent technical improvements have unveiled the complex crosstalk between RNAs and T cells. Moreover, resting T cells contain large amounts of untranslated mRNAs, implying that the regulation of RNA metabolism might be a key step in controlling gene expression. Considering the immunological significance of T cells for disease treatment, an understanding of RNA metabolism in T cells could provide new directions in harnessing T cells for therapeutic implications.
Files in This Item:
T202205523.pdf Download
DOI
10.4110/in.2022.22.e39
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Hwang, Soo Seok(황수석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193867
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