자기공명분자영상 응용을 위한 자성 마이크로 니들의 제조와 특성분석

Abstract

In this study, magnetized microneedles (MMNs) that contain herceptin conjugated to iron oxide nanoparticles were manufactured by low temperature process technology and its effects on magnetic resonance (MR) molecular imaging were investigated. The results showed that after the MMNs were manufactured, changes in morphology and magnetic properties were not observed and more than 90% of the skin permeability and cell viability were confirmed and dramatic signal intensity changes of MMNs containing herceptin were confirmed more than 30% on magnetic resonance imaging measurements. In conclusion, it is expected that MMNs containing herceptin have an essential role as a base technology in the field of MR molecular imaging, which can diagnose and therapeutic through transdermal drug delivery system.