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Associations of biomarkers for exposure to tobacco smoke with lung cancer risk in Korea

Authors
 Guen Hui Kim  ;  Joyce Mary Kim  ;  Sun Ha Jee  ;  Keum Ji Jung 
Citation
 CANCER BIOMARKERS, Vol.35(4) : 409-417, 2022-06 
Journal Title
CANCER BIOMARKERS
ISSN
 1574-0153 
Issue Date
2022-06
MeSH
Biomarkers ; Humans ; Lung Neoplasms* / epidemiology ; Lung Neoplasms* / etiology ; Nicotine / analysis ; Republic of Korea / epidemiology ; Smoking / adverse effects ; Tobacco ; Tobacco Smoke Pollution*
Keywords
Lung cancer ; biomarkers ; cotinine ; nicotine metabolite ratio ; smoking
Abstract
Background: Nicotine metabolite ratio (NMR) can be used to predict total nicotine clearance. However, it is unknown whether NMR could be used as a marker of lung cancer risk.

Objective: To evaluate the blood metabolites of nicotine relating to the risk of developing lung cancer and investigate the combined effects of NMR and cigarette per day on the risk of lung cancer.

Methods: Among the 1,054 eligible subjects from the Korean Cancer Prevention Study-II biobank cohort, those with cotinine values below 0 ng/ml were excluded. Slow and fast metabolizer groups were defined using the median value of the NMR, calculated with the control group data, as the cut-point.

Results: The multivariable Cox proportional hazard models demonstrated that, the fast metabolizer group had a significantly higher risk of lung cancer than the slow metabolizer group (Adjusted HR: 2.02, 95% CI: 1.32-3.10). Fast metabolizers who smoked more than 15 cigarettes per day had an even higher risk of lung cancer (Adjusted HR: 3.51, 95% CI: 1.96-6.29) than the slow metabolizers who smoked less than 15 cigarettes per day.

Conclusions: In summary, the NMR may be an effective marker for estimating tobacco-related disease risks such as lung cancer.
Full Text
https://content.iospress.com/articles/cancer-biomarkers/cbm220023
DOI
10.3233/CBM-220023
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193800
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