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Associations of biomarkers for exposure to tobacco smoke with lung cancer risk in Korea

DC Field Value Language
dc.contributor.author정금지-
dc.contributor.author지선하-
dc.date.accessioned2023-04-07T01:11:20Z-
dc.date.available2023-04-07T01:11:20Z-
dc.date.issued2022-06-
dc.identifier.issn1574-0153-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193800-
dc.description.abstractBackground: Nicotine metabolite ratio (NMR) can be used to predict total nicotine clearance. However, it is unknown whether NMR could be used as a marker of lung cancer risk. Objective: To evaluate the blood metabolites of nicotine relating to the risk of developing lung cancer and investigate the combined effects of NMR and cigarette per day on the risk of lung cancer. Methods: Among the 1,054 eligible subjects from the Korean Cancer Prevention Study-II biobank cohort, those with cotinine values below 0 ng/ml were excluded. Slow and fast metabolizer groups were defined using the median value of the NMR, calculated with the control group data, as the cut-point. Results: The multivariable Cox proportional hazard models demonstrated that, the fast metabolizer group had a significantly higher risk of lung cancer than the slow metabolizer group (Adjusted HR: 2.02, 95% CI: 1.32-3.10). Fast metabolizers who smoked more than 15 cigarettes per day had an even higher risk of lung cancer (Adjusted HR: 3.51, 95% CI: 1.96-6.29) than the slow metabolizers who smoked less than 15 cigarettes per day. Conclusions: In summary, the NMR may be an effective marker for estimating tobacco-related disease risks such as lung cancer.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherIOS Press-
dc.relation.isPartOfCANCER BIOMARKERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBiomarkers-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms* / epidemiology-
dc.subject.MESHLung Neoplasms* / etiology-
dc.subject.MESHNicotine / analysis-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHSmoking / adverse effects-
dc.subject.MESHTobacco-
dc.subject.MESHTobacco Smoke Pollution*-
dc.titleAssociations of biomarkers for exposure to tobacco smoke with lung cancer risk in Korea-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorGuen Hui Kim-
dc.contributor.googleauthorJoyce Mary Kim-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorKeum Ji Jung-
dc.identifier.doi10.3233/CBM-220023-
dc.contributor.localIdA03580-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ03611-
dc.identifier.eissn1875-8592-
dc.identifier.pmid36373307-
dc.identifier.urlhttps://content.iospress.com/articles/cancer-biomarkers/cbm220023-
dc.subject.keywordLung cancer-
dc.subject.keywordbiomarkers-
dc.subject.keywordcotinine-
dc.subject.keywordnicotine metabolite ratio-
dc.subject.keywordsmoking-
dc.contributor.alternativeNameJung, Keum Ji-
dc.contributor.affiliatedAuthor정금지-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume35-
dc.citation.number4-
dc.citation.startPage409-
dc.citation.endPage417-
dc.identifier.bibliographicCitationCANCER BIOMARKERS, Vol.35(4) : 409-417, 2022-06-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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