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Molecular and radiopathologic spectrum between HCC and intrahepatic cholangiocarcinoma

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dc.contributor.author박영년-
dc.contributor.author유정은-
dc.contributor.author이형진-
dc.contributor.author정택-
dc.date.accessioned2023-03-27T02:57:33Z-
dc.date.available2023-03-27T02:57:33Z-
dc.date.issued2023-01-
dc.identifier.issn0270-9139-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193749-
dc.description.abstractBackground and aims: Primary liver cancers (LCs), including HCC and intrahepatic cholangiocarcinoma (iCCA), are derived from a common developmental lineage, conferring a molecular spectrum between them. To elucidate the molecular spectrum, we performed an integrative analysis of transcriptome profiles associated with patients' radiopathologic features. Approach and results: We identified four LC subtypes (LC1-LC4) from RNA-sequencing profiles, revealing intermediate subtypes between HCC and iCCA. LC1 is a typical HCC characterized by active bile acid metabolism, telomerase reverse transcriptase promoter mutations, and high uptake of gadoxetic acid in MRI. LC2 is an iCCA-like HCC characterized by expression of the progenitor cell-like trait, tumor protein p53 mutations, and rim arterial-phase hyperenhancement in MRI. LC3 is an HCC-like iCCA, mainly small duct (SD) type, associated with HCC-related etiologic factors. LC4 is further subclassified into LC4-SD and LC4-large duct iCCAs according to the pathological features, which exhibited distinct genetic variations (e.g., KRAS , isocitrate dehydrogenase 1/2 mutation, and FGF receptor 2 fusion), stromal type, and prognostic outcomes. Conclusions: Our integrated view of the molecular spectrum of LCs can identify subtypes associated with transcriptomic, genomic, and radiopathologic features, providing mechanistic insights into heterogeneous LC progression.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfHEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBile Duct Neoplasms* / diagnostic imaging-
dc.subject.MESHBile Duct Neoplasms* / genetics-
dc.subject.MESHBile Duct Neoplasms* / metabolism-
dc.subject.MESHBile Ducts, Intrahepatic / pathology-
dc.subject.MESHCarcinoma, Hepatocellular* / diagnostic imaging-
dc.subject.MESHCarcinoma, Hepatocellular* / genetics-
dc.subject.MESHCarcinoma, Hepatocellular* / metabolism-
dc.subject.MESHCholangiocarcinoma* / diagnostic imaging-
dc.subject.MESHCholangiocarcinoma* / genetics-
dc.subject.MESHCholangiocarcinoma* / metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms* / diagnostic imaging-
dc.subject.MESHLiver Neoplasms* / genetics-
dc.subject.MESHLiver Neoplasms* / metabolism-
dc.titleMolecular and radiopathologic spectrum between HCC and intrahepatic cholangiocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorYoungsic Jeon-
dc.contributor.googleauthorSo Mee Kwon-
dc.contributor.googleauthorHyungjin Rhee-
dc.contributor.googleauthorJeong Eun Yoo-
dc.contributor.googleauthorTaek Chung-
dc.contributor.googleauthorHyun Goo Woo-
dc.contributor.googleauthorYoung Nyun Park-
dc.identifier.doi10.1002/hep.32397-
dc.contributor.localIdA01563-
dc.contributor.localIdA02504-
dc.contributor.localIdA05171-
dc.relation.journalcodeJ00985-
dc.identifier.eissn1527-3350-
dc.identifier.pmid35124821-
dc.identifier.urlhttps://journals.lww.com/hep/Fulltext/2023/01010/Molecular_and_radiopathologic_spectrum_between_HCC.13.aspx-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.affiliatedAuthor박영년-
dc.contributor.affiliatedAuthor유정은-
dc.contributor.affiliatedAuthor이형진-
dc.citation.volume77-
dc.citation.number1-
dc.citation.startPage92-
dc.citation.endPage108-
dc.identifier.bibliographicCitationHEPATOLOGY, Vol.77(1) : 92-108, 2023-01-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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