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Dosimetric comparison of robust angles in carbon-ion radiation therapy for prostate cancer

Authors
 Han-Back Shin  ;  Changhwan Kim  ;  Min Cheol Han  ;  Chae-Seon Hong  ;  Seyjoon Park  ;  Woong Sub Koom  ;  Jin Sung Kim 
Citation
 FRONTIERS IN ONCOLOGY, Vol.13 : 1054693, 2023-02 
Journal Title
FRONTIERS IN ONCOLOGY
Issue Date
2023-02
Keywords
LET value ; RBE-weighted dose ; carbon-ion radiation therapy ; dosimetric study ; particle therapy ; prostate cancer
Abstract
The objective of this study is to compare the plan robustness at various beam angles. Hence, the influence of the beam angles on robustness and linear energy transfer (LET) was evaluated in gantry-based carbon-ion radiation therapy (CIRT) for prostate cancer. 10 patients with prostate cancer were considered, and a total dose of 51.6 Gy (Relative biological effectiveness (RBE) was prescribed for the target volume in 12 fractions. Five beam field plans comprising two opposed fields with different angle pairs were characterized. Further, dose parameters were extracted, and the RBE-weighted dose and LET values for all angle pairs were compared. All plans considering the setup uncertainty satisfied the dose regimen. When a parallel beam pair was used for perturbed scenarios to take into account set-up uncertainty in the anterior direction, the LET clinical treatment volume (CTV) D 95% standard deviation was 1.5 times higher, and the standard deviation of RBE-weighted CTV D 95% was 7.9 times higher compared to an oblique pair. The oblique beam fields were superior in terms of dose sparing for the rectum compared to the dose distribution using two conventional lateral opposed fields for prostate cancer.
Files in This Item:
T202301649.pdf Download
DOI
10.3389/fonc.2023.1054693
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Jinsung(김진성) ORCID logo https://orcid.org/0000-0003-1415-6471
Kim, Changhwan(김창환)
Shin, Han-Back(신한백)
Han, Min Cheol(한민철)
Hong, Chae-Seon(홍채선) ORCID logo https://orcid.org/0000-0001-9120-6132
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193738
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