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Association between smoking cessation and non-alcoholic fatty liver disease using NAFLD liver fat score

Authors
 Yun Seo Jang  ;  Hye Jin Joo  ;  Yu Shin Park  ;  Eun-Cheol Park  ;  Sung-In Jang 
Citation
 FRONTIERS IN PUBLIC HEALTH, Vol.11 : 1015919, 2023-02 
Journal Title
FRONTIERS IN PUBLIC HEALTH
Issue Date
2023-02
MeSH
Humans ; Male ; Non-alcoholic Fatty Liver Disease* ; Nutrition Surveys ; Smoking ; Smoking Cessation*
Keywords
nonalcoholic fatty liver disease ; pack-years ; smoking ; smoking behavior ; smoking cessation ; smoking history ; tobacco
Abstract
Background: Smoking is well known to be associated with a higher prevalence and incidence of liver diseases such as advanced fibrosis. However, the impact of smoking on developing nonalcoholic fatty liver disease remains controversial, and clinical data on this is limited. Therefore, this study aimed to investigate the association between smoking history and nonalcoholic fatty liver disease (NAFLD).

Methods: Data from the Korea National Health and Nutrition Examination Survey 2019-2020 were used for the analysis. NAFLD was diagnosed according to an NAFLD liver fat score of >-0.640. Smoking status was classified as into nonsmokers, ex-smokers, and current smokers. Multiple logistic regression analysis was conducted to examine the association between smoking history and NAFLD in the South Korean population.

Results: In total, 9,603 participants were enrolled in this study. The odds ratio (OR) for having NAFLD in ex-smokers and current smokers in males was 1.12 (95% confidence interval [CI]: 0.90-1.41) and 1.38 (95% CI: 1.08-1.76) compared to that in nonsmokers, respectively. The OR increased in magnitude with smoking status. Ex-smokers who ceased smoking for <10 years (OR: 1.33, 95% CI: 1.00-1.77) were more likely to have a strong correlation with NAFLD. Furthermore, NAFLD had a dose-dependent positive effect on pack-years, which was 10 to 20 (OR: 1.39, 95% CI: 1.04-1.86) and over 20 (OR: 1.51, 95% CI: 1.14-2.00).

Conclusion: This study found that smoking may contribute to NAFLD. Our study suggests cessation of smoking may help management of NAFLD.
Files in This Item:
T202301605.pdf Download
DOI
10.3389/fpubh.2023.1015919
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
Jang, Sung In(장성인) ORCID logo https://orcid.org/0000-0002-0760-2878
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193696
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