Cited 2 times in
Albumin, filamin-A and cytokeratin 19 help distinguish intrahepatic cholangiocarcinoma from extrahepatic adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 김현기 | - |
dc.contributor.author | 류향주 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 유정은 | - |
dc.contributor.author | 이형진 | - |
dc.contributor.author | 정연승 | - |
dc.contributor.author | 정택 | - |
dc.date.accessioned | 2023-03-22T02:33:07Z | - |
dc.date.available | 2023-03-22T02:33:07Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 1936-0533 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193626 | - |
dc.description.abstract | Background: The differential diagnosis of intrahepatic cholangiocarcinomas (iCCAs) from metastatic adenocarcinomas from organs adjacent to the liver (gallbladder, pancreas, and stomach) is difficult due to histopathological similarity and a lack of specific markers. This study aimed to develop a method to differentiate iCCA and adenocarcinomas originated from extrahepatic organs adjacent to the liver. Methods: We retrospectively enrolled surgically resected iCCA (n = 181) and adenocarcinomas from extrahepatic organs (n = 30, n = 28, and n = 38 from gallbladder, pancreas, and stomach, respectively) between 2007 and 2013. The albumin mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) of filamin-A and cytokeratin 19 (CK19) were performed using tissue microarray. Using logistic regression analysis of three markers, iCCA-score was developed, and its diagnostic performance was evaluated. Results: The iCCAs were more frequently positive for albumin ISH (23.2% vs. 0%), filamin-A IHC (47.5% vs. 12.5%) and CK19 (68.5% vs. 40.6%) than extrahepatic adenocarcinomas (p < 0.001 for all). The iCCA-score consisting of these three markers was developed, and it showed higher diagnostic performance (area under the curve [AUC], 0.798 vs. 0.616, p < 0.001). Taking an iCCA-score of 2 or higher as the threshold for iCCA, the sensitivity was substantially higher than albumin ISH alone (45.9% and 23.2%, respectively; p < 0.001), but maintained high specificity (94.8% and 100%, respectively). Conclusion: Albumin ISH and IHC staining for filamin-A and CK19 showed distinct expression patterns between iCCA and extrahepatic adenocarcinomas from gallbladder, pancreas, and stomach. We developed iCCA-score that consisted of those three markers, and it showed better diagnostic performance than albumin ISH alone. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | HEPATOLOGY INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenocarcinoma* / diagnosis | - |
dc.subject.MESH | Adenocarcinoma* / genetics | - |
dc.subject.MESH | Albumins | - |
dc.subject.MESH | Bile Duct Neoplasms* / genetics | - |
dc.subject.MESH | Bile Ducts, Intrahepatic / chemistry | - |
dc.subject.MESH | Bile Ducts, Intrahepatic / metabolism | - |
dc.subject.MESH | Bile Ducts, Intrahepatic / pathology | - |
dc.subject.MESH | Biomarkers, Tumor | - |
dc.subject.MESH | Cholangiocarcinoma* / diagnosis | - |
dc.subject.MESH | Cholangiocarcinoma* / genetics | - |
dc.subject.MESH | Filamins / genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keratin-19 / genetics | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Albumin, filamin-A and cytokeratin 19 help distinguish intrahepatic cholangiocarcinoma from extrahepatic adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Yeon Seung Chung | - |
dc.contributor.googleauthor | Youngsic Jeon | - |
dc.contributor.googleauthor | Jeong Eun Yoo 1 | - |
dc.contributor.googleauthor | Taek Chung | - |
dc.contributor.googleauthor | Hyang Joo Ryu | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Hyungjin Rhee | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.identifier.doi | 10.1007/s12072-022-10428-2 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A06168 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A02504 | - |
dc.contributor.localId | A05171 | - |
dc.relation.journalcode | J00986 | - |
dc.identifier.eissn | 1936-0541 | - |
dc.identifier.pmid | 36253584 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s12072-022-10428-2 | - |
dc.subject.keyword | Albumin | - |
dc.subject.keyword | CK19 | - |
dc.subject.keyword | Cholangiocarcinoma | - |
dc.subject.keyword | Diagnosis, Differential | - |
dc.subject.keyword | Extrahepatic adenocarcinoma | - |
dc.subject.keyword | Filamin-A | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | In situ hybridization | - |
dc.subject.keyword | Neoplasm metastasis | - |
dc.subject.keyword | Pathology | - |
dc.contributor.alternativeName | Kim, Hyunki | - |
dc.contributor.affiliatedAuthor | 김현기 | - |
dc.contributor.affiliatedAuthor | 류향주 | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.contributor.affiliatedAuthor | 유정은 | - |
dc.contributor.affiliatedAuthor | 이형진 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 77 | - |
dc.citation.endPage | 85 | - |
dc.identifier.bibliographicCitation | HEPATOLOGY INTERNATIONAL, Vol.17(1) : 77-85, 2023-02 | - |
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