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Changes in mechanical and bacterial properties of denture base resin following nanoceria incorporation with and without SBA-15 carriers

Authors
 Utkarsh Mangal  ;  Ji-Young Seo  ;  Jeong-Hyun Ryu  ;  Jie Jin  ;  Chengzan Wu  ;  Jung-Yul Cha  ;  Kee-Joon Lee  ;  Hyung-Seog Yu  ;  Kwang-Mahn Kim  ;  Jae-Sung Kwon  ;  Sung-Hwan Choi 
Citation
 JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol.138 : 105634, 2023-02 
Journal Title
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
ISSN
 1751-6161 
Issue Date
2023-02
MeSH
Denture Bases* ; Materials Testing ; Polymethyl Methacrylate* ; Silicon Dioxide ; Surface Properties
Keywords
Ceria nanoparticle ; Cytocompatibility ; Mesoporous silica nanoparticle ; Multispecies biofilm resistance ; PMMA ; SBA-15
Abstract
Poly (methyl methacrylate) (PMMA) is a commonly used material for the fabrication of biomedical appliances. Although PMMA has several advantages, it is susceptible to microbial insults with practical use. Therefore, different bioactive nanomaterials, such as nanoceria (CeN), have been proposed to enhance the properties of PMMA. In this study, we investigated the effect of the incorporation of CeN into PMMA with and without the use of mesoporous silica nanoparticle (SBA-15) carriers. The unmodified PMMA specimens (control, CTRL) were compared to groups containing SBA-15, CeN, and the synthesized SBA-15 impregnated with CeN (SBA-15@CeN) at different loading percentages. The mechanical and physical properties of the different SBA-15@CeN groups and their effects on cell viability were investigated, and the optimal CeN concentration was identified accordingly. Our results revealed that flexural strength was significantly (P < 0.01) reduced in the SBA-15@CeN3× group (containing 3-fold the CeN wt. %). Although the surface microhardness increased with the increase in the wt. % of SBA-15@CeN, cell viability was significantly reduced (P < 0.001). The SBA-15@CeN1× group had the optimal concentration and displayed significant resistance to single-and multispecies microbial colonization. Finally, the enzymatic activity of CeN was significantly high in the SBA-15@CeN1× group. The proinflammatory markers (IL-6, IL-1β, TNF-α, CD80, and CD86) showed a significant (P < 0.001) multifold reduction in lipopolysaccharide-induced RAW cells treated with a 5-day eluate of the SBA-15@CeN1× group. These results indicate that the addition of SBA-15@CeN at 1.5 wt % improves the biological response of PMMA without compromising its mechanical properties.
Full Text
https://www.sciencedirect.com/science/article/pii/S1751616122005392
DOI
10.1016/j.jmbbm.2022.105634
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Yu, Hyung Seog(유형석) ORCID logo https://orcid.org/0000-0002-1275-5078
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Cha, Jung Yul(차정열)
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193611
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