Cited 2 times in
Association of short-term and long-term weight loss with the risk of major adverse cardiovascular disease: Community-based cohort study
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 강이화 | - |
dc.contributor.author | 김형우 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 윤해룡 | - |
dc.contributor.author | 주영수 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2023-03-22T02:29:14Z | - |
dc.date.available | 2023-03-22T02:29:14Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193609 | - |
dc.description.abstract | Background: This study evaluated temporal association of changes in BMI over time with major adverse cardiovascular event (MACE) in Korean middle-aged adults. Methods: Between 2001 and 2002, 6855 individuals from the Korean Genome and Epidemiology Study were included and followed up until 2014. The main predictor was the change in BMI determined using group-based trajectory modelling (decreasing, stable, and increasing) from the baseline to 4-, 6-, and 8-years of follow-up. The primary outcome was the occurrence of MACE. Results: During the mean 10.2 years follow-up, MACEs occurred in 350 (5.1 %) individuals. The median (interquartile rage) age of study population was 50 (44-59) years. In primary analysis with 4-year trajectory model, decreasing BMI trajectory was associated with a 1.41-fold higher risk of the MACEs (hazard ratio [HR], 1.41; 95 % confidence interval [CI], 1.06-1.91) compared with stable BMI trajectory. In secondary analyses with 6- and 8-year trajectory models, this association disappeared, and the corresponding HRs (95 % CIs) were 1.14 (0.81-1.61) and 0.98 (0.65-1.49), respectively. There were concomitant improvements in cardiometabolic risk factors in decreasing BMI group, but unfavorable risk burden remained up to 4 to 6 years. Conclusions: The initial 4-year weight loss was paradoxically associated with a higher risk of MACEs, probably due to residual cardiovascular burden. However, this association became null in participants with sustained weight loss ≥ 6 years, suggesting a possible lag effect of weight loss on MACEs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cardiovascular Diseases* / epidemiology | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Weight Loss | - |
dc.title | Association of short-term and long-term weight loss with the risk of major adverse cardiovascular disease: Community-based cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hae-Ryong Yun | - |
dc.contributor.googleauthor | Young Su Joo | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Ea Wha Kang | - |
dc.contributor.googleauthor | Nak-Hoon Son | - |
dc.contributor.googleauthor | Hyung Woo Kim | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.1016/j.diabres.2022.110193 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00074 | - |
dc.contributor.localId | A01151 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04617 | - |
dc.contributor.localId | A03956 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 36464088 | - |
dc.identifier.url | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0168822722010075 | - |
dc.subject.keyword | Blood pressure | - |
dc.subject.keyword | Body mass index | - |
dc.subject.keyword | Dyslipidemia | - |
dc.subject.keyword | Group-based trajectory modelling | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Insulin Resistance | - |
dc.subject.keyword | Major adverse cardiovascular events | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 강이화 | - |
dc.contributor.affiliatedAuthor | 김형우 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 윤해룡 | - |
dc.contributor.affiliatedAuthor | 주영수 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 195 | - |
dc.citation.startPage | 110193 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.195 : 110193, 2023-01 | - |
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