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Altered gut microbiota in individuals with episodic and chronic migraine

 Dongeun Yong  ;  Hakbae Lee  ;  Hyung-Gyu Min  ;  Kyungnam Kim  ;  Hyun-Seok Oh  ;  Min Kyung Chu 
 SCIENTIFIC REPORTS, Vol.13(1) : 626, 2023-01 
Journal Title
Issue Date
Case-Control Studies ; Cross-Sectional Studies ; Gastrointestinal Microbiome* ; Headache ; Humans ; Migraine Disorders* ; RNA, Ribosomal, 16S / genetics
Emerging evidence reveals a close association between gut microbiota and human neurological disorders. The present study aimed to assess whether the composition of gut microbiota in participants with episodic migraine (EM) and chronic migraine (CM) was altered in comparison to that of the controls. This study was a cross-sectional, case-control study. The gut microbiota were evaluated by the partial, targeted sequencing of the 16S rRNA V3-V4 region. This study enrolled 42 and 45 participants with EM and CM, respectively, and 43 controls. Alpha and beta diversities revealed no significant difference among the three groups; however, the microbiota composition at the class, order, family, and genus levels differed significantly between EM and the control, CM and the control, and the EM and CM groups. Moreover, higher composition of PAC000195_g was significantly associated with a lower headache frequency among the five genera that exhibited significantly different microbiota composition in EM and CM. Agathobacter revealed a significant negative association with severe headache intensity. The findings of the present study provide evidence of altered gut microbiota in EM and CM. These findings will help in understanding the course and treatment of migraine.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Chu, Min Kyung(주민경) ORCID logo https://orcid.org/0000-0001-6221-1346
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