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Polybetaine-enhanced hybrid ionomer cement shows improved total biological effect with bacterial resistance and cellular stimulation

 Utkarsh Mangal   ;   Tae-Yun Kang  ;   Ju Won Jung  ;   Ji-Yeong Kim  ;   Ji-Young Seo 1  ;   Jung-Yul Cha  ;   Kee-Joon Lee  ;   Hyung-Seog Yu   ;   Kwang-Mahn Kim  ;   Jin-Man Kim  ;   Jae-Sung Kwon  ;   Sung-Hwan Choi 
 BIOMATERIALS SCIENCE, Vol.11(2) : 554-566, 2023-01 
Journal Title
Issue Date
Bone Cements ; Fluorides* ; Glass Ionomer Cements* ; Humans ; Materials Testing
Hybrid ionomer cements (HICs) are aesthetic polyelectrolyte cements that have been modified with a resin. The setting of HICs occurs by both monomer polymerization and an acid-base reaction. In addition, HICs contain a resin, which is substituted for water. Thus, the competition between the setting reactions and reduced water content inherently limits polysalt formation and, consequently the bioactive interactions. In this study, we explored the effects of polybetaine zwitterionic derivatives (mZMs) on the augmentation of the bioactive response of HICs. The polybetaines were homogenized into an HIC in different proportions (α, β, and γ) at 3% w/v. Following basic characterization, the bioactive response of human dental pulp stem cells (hDPSCs) was evaluated. The augmented release of the principal constituent ions (strontium, silica, and fluoride) from the HIC was observed with the addition of the mZMs. Modification with α-mZM elicited the most favorable bioactive response, namely, increased ion elution, in vitro calcium phosphate precipitation, and excellent biofouling resistance, which deterred the growth of the bridging species of Veillonella. Moreover, α-mZM resulted in a significant increase in the hDPSC response, as confirmed by a significant increase (p < 0.05) in alizarin red staining. The results of mRNA expression tests, performed using periodically refreshed media, showed increased and early peak expression levels for RUNX2, OCN, and OPN in the case of α-mZM. Based on the results of the in vitro experiments, it can be concluded that modification of HICs with polybetaine α-mZM can augment the overall biological response.
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Tae-Yun(강태윤) ORCID logo https://orcid.org/0000-0003-0447-9605
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Mangal, Utkarsh(만갈웃커시)
Yu, Hyung Seog(유형석) ORCID logo https://orcid.org/0000-0002-1275-5078
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Cha, Jung Yul(차정열)
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
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