47 134

Cited 0 times in

Impact of thyroid cancer on the cancer risk in patients with non‑alcoholic fatty liver disease or dyslipidemia

 Joon Ho  ;  Eunhwa Kim  ;  Myeongjee Lee  ;  Inkyung Jung  ;  Young Suk Jo  ;  Jandee Lee 
 SCIENTIFIC REPORTS, Vol.13(1) : 1076, 2023-01 
Journal Title
Issue Date
Dyslipidemias* / complications ; Dyslipidemias* / epidemiology ; Humans ; Male ; Non-alcoholic Fatty Liver Disease* / complications ; Non-alcoholic Fatty Liver Disease* / epidemiology ; Obesity ; Risk Factors ; Thyroid Neoplasms* / complications ; Thyroid Neoplasms* / epidemiology
The raised prevalence of obesity has increased the incidence of obesity-related metabolic diseases such as dyslipidemia (DL) and non-alcoholic fatty liver disease (NAFLD), along with the development and progression of various types of cancer, including thyroid cancer. In this study, we investigated whether thyroid cancer in patients with DL and NAFLD could be a risk factor for other cancers. To achieve our goal, we generated two independent cohorts from our institution and from the National Health Insurance System in South Korea. Based on the ICD-10 code, we conducted exact matching (1:5 matching) and estimated the overall risk of thyroid cancer for other cancers in patients with DL or NAFLD. Univariate and multivariate analyses showed that the hazard ratio (HR) of thyroid cancer was 2.007 (95% Confidence Interval [CI], 1.597-2.522) and 2.092 (95% CI, 1.546-2.829), respectively in the institutional cohort and 1.329 (95% CI, 1.153-1.533) and 1.301 (95% CI, 1.115-1.517), respectively in the nationwide cohort. Risk analysis revealed a significant increase in the HR in lip, tongue, mouth, lung, bone, joint, soft tissue, skin, brain, male cancers and lymphoma after thyroid cancer occurred. Thyroid cancer in patients with DL or NAFLD might be a valuable factor for predicting the development of other cancers.
Files in This Item:
T202300548.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Myeongjee(이명지)
Lee, Jan Dee(이잔디) ORCID logo https://orcid.org/0000-0003-4090-0049
Jung, Inkyung(정인경) ORCID logo https://orcid.org/0000-0003-3780-3213
Jo, Young Suk(조영석) ORCID logo https://orcid.org/0000-0001-9926-8389
Ho, Joon(허준) ORCID logo https://orcid.org/0000-0001-9782-0432
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.