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Emergence of NDM-1-producing Pseudomonas aeruginosa Sequence Type 773 Clone: Shift of Carbapenemase Molecular Epidemiology and Spread of 16S rRNA Methylase Genes in Korea

Authors
 Yu Jeong Choi  ;  Young Ah Kim  ;  Kim Junglim  ;  Seok Hoon Jeong  ;  Jong Hee Shin  ;  Kyeong Seob Shin  ;  Jeong Hwan Shin  ;  Young Ree Kim  ;  Hyun Soo Kim  ;  Young Uh  ;  Nam Hee Ryoo 
Citation
 ANNALS OF LABORATORY MEDICINE, Vol.43(2) : 196-199, 2023-03 
Journal Title
ANNALS OF LABORATORY MEDICINE
ISSN
 2234-3806 
Issue Date
2023-03
MeSH
Amikacin / pharmacology ; Anti-Bacterial Agents / pharmacology ; Anti-Infective Agents* ; Bacterial Proteins / genetics ; Carbapenems / pharmacology ; Clone Cells ; Humans ; Microbial Sensitivity Tests ; Molecular Epidemiology ; Pseudomonas Infections* / diagnosis ; Pseudomonas Infections* / epidemiology ; Pseudomonas aeruginosa / genetics ; RNA, Ribosomal, 16S / genetics ; beta-Lactamases / genetics
Keywords
16S rRNA methylase gene ; Amikacin ; Molecular Epidemiology ; Pseudomonas aeruginosa ; Sequence type 773 ; β-lactamase NDM-1
Abstract
Imipenemase (IMP)-6-producing Pseudomonas aeruginosa sequence type (ST) 235 is a dominant clone of carbapenemase-producing P. aeruginosa (CPPAE) in Korea. As part of the Antimicrobial Resistance Surveillance System in Korea, we found an increase in the carbapenem resistance rate of P. aeruginosa isolates from blood cultures and a shift in the molecular epidemiology of CPPAE. A total of 212 non-duplicated P. aeruginosa blood isolates were obtained from nine general hospitals and two nursing homes. Twenty-four isolates were identified as CPPAE. We observed the emergence of the NDM-1 P. aeruginosa ST 773 clone (N=10), mostly from Gyeongsang Province. The IMP-6 ST 235 clone (N=11) was detected in all provinces. CPPAE isolates showed very high resistance rates to amikacin, and all NDM-1 P. aeruginosa strains carried rmtB. This is the first nationwide surveillance of the recently emerged NDM-1-producing P. aeruginosa ST773 clone in Korea. Continuous surveillance is necessary to prevent the infection and transmission of carbapenem- and amikacin-resistant P. aeruginosa in Korea.
Files in This Item:
T202205735.pdf Download
DOI
10.3343/alm.2023.43.2.196
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193505
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