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A randomized multicenter evaluation of the efficacy of 0.15% hyaluronic acid versus 0.05% cyclosporine A in dry eye syndrome

Authors
 Ji Eun Lee  ;  Sangyoon Kim  ;  Hyung Keun Lee  ;  Tae-Young Chung  ;  Jae Yong Kim  ;  Chul Young Choi  ;  So Hyang Chung  ;  Dong Hyun Kim  ;  Kyoung Woo Kim  ;  Jin Kwon Chung  ;  Kyu Yeon Hwang  ;  Ho Sik Hwang  ;  Jin Hyoung Kim  ;  Joon Young Hyon 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 18737, 2022-11 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-11
MeSH
Cyclosporine* / adverse effects OR Dry Eye Syndromes* / chemically induced OR Dry Eye Syndromes* / drug therapy OR Humans OR Hyaluronic Acid / adverse effects OR Ophthalmic Solutions / therapeutic use OR Tears
Abstract
Hyaluronic acid (HA) and cyclosporine A (CsA) eyedrops are commonly prescribed in dry eye syndrome (DES). The effectiveness of each preparation in DES is well-known, yet the superiority of one over another has been studied little. We assessed the efficacy and tolerability of 0.15% HA compared to combinations of 0.05% CsA plus 0.5% carboxymethylcellulose (CMC), and 0.15% HA plus 0.05% CsA in patients with moderate to severe DES. Total 438 patients with moderate to severe DES were recruited and randomized for one of the three treatments for 12 weeks. Effectiveness was assessed at baseline, 4- and 12-weeks. The primary endpoint was change in corneal staining score. The secondary endpoints were tear break-up time (TBUT), strip meniscometry (SM) score, ocular surface disease index (OSDI) score, and tolerability questionnaire. The change in corneal staining score for 0.15% HA from the baseline was non-inferior to that of 0.05% CsA. Corneal staining score, TBUT, SM score, and OSDI score improved in all groups without statistically significant intergroup differences. Better tolerability and lower prevalence of adverse drug reactions were seen in 0.15% HA. Our findings suggest that 0.15% HA may be equivalently effective and safer than 0.05% CsA in treating moderate to severe DES.
Files in This Item:
T202302365.pdf Download
DOI
10.1038/s41598-022-21330-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193327
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