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Generation of two PITX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system

Authors
 Dasom Mun  ;  Ji-Young Kang  ;  Yumin Chun  ;  Da-Seul Park  ;  Hyoeun Kim  ;  Nuri Yun  ;  Seung-Hyun Lee  ;  Boyoung Joung 
Citation
 STEM CELL RESEARCH, Vol.65 : 102940, 2022-12 
Journal Title
STEM CELL RESEARCH
ISSN
 1873-5061 
Issue Date
2022-12
MeSH
Atrial Fibrillation* ; CRISPR-Cas Systems / genetics ; Humans ; Induced Pluripotent Stem Cells*
Abstract
PITX2 is a homeobox gene located in the human 4q25 locus and is commonly associated with atrial fibrillation (AF). Here, we generated two PITX2 knock-out human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 genome editing. The edited iPSCs maintained fullpluripotency, normal karyotype and spontaneousdifferentiation capability. This cell line provides a suitable model for investigating the physiopathologyof PITX2 mutation in atrial fibrillation.
Full Text
https://www.sciencedirect.com/science/article/pii/S1873506122002896?
DOI
10.1016/j.scr.2022.102940
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hyun(이승현) ORCID logo https://orcid.org/0000-0001-7549-9430
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193320
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