Cited 3 times in
Generation of two PITX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승현 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2023-03-21T07:20:35Z | - |
dc.date.available | 2023-03-21T07:20:35Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1873-5061 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193320 | - |
dc.description.abstract | PITX2 is a homeobox gene located in the human 4q25 locus and is commonly associated with atrial fibrillation (AF). Here, we generated two PITX2 knock-out human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 genome editing. The edited iPSCs maintained fullpluripotency, normal karyotype and spontaneousdifferentiation capability. This cell line provides a suitable model for investigating the physiopathologyof PITX2 mutation in atrial fibrillation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | STEM CELL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Atrial Fibrillation* | - |
dc.subject.MESH | CRISPR-Cas Systems / genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Induced Pluripotent Stem Cells* | - |
dc.title | Generation of two PITX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.googleauthor | Dasom Mun | - |
dc.contributor.googleauthor | Ji-Young Kang | - |
dc.contributor.googleauthor | Yumin Chun | - |
dc.contributor.googleauthor | Da-Seul Park | - |
dc.contributor.googleauthor | Hyoeun Kim | - |
dc.contributor.googleauthor | Nuri Yun | - |
dc.contributor.googleauthor | Seung-Hyun Lee | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.1016/j.scr.2022.102940 | - |
dc.contributor.localId | A02932 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J02680 | - |
dc.identifier.eissn | 1876-7753 | - |
dc.identifier.pmid | 36260954 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1873506122002896? | - |
dc.contributor.alternativeName | Lee, Seung Hyun | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 65 | - |
dc.citation.startPage | 102940 | - |
dc.identifier.bibliographicCitation | STEM CELL RESEARCH, Vol.65 : 102940, 2022-12 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.