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Generation of two PITX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system

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dc.contributor.authorMun, Dasom-
dc.contributor.authorKANG, JIYOUNG-
dc.contributor.authorChun, Yumin-
dc.contributor.authorPark, Da-Seul-
dc.contributor.authorKim, Hyoeun-
dc.contributor.authorYun, Nuri-
dc.contributor.authorLee , Seung hyun-
dc.contributor.authorJoung, Bo Young-
dc.date.accessioned2023-03-21T07:20:35Z-
dc.date.available2023-03-21T07:20:35Z-
dc.date.created2023-01-19-
dc.date.issued2022-12-
dc.identifier.issn1873-5061-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193320-
dc.description.abstractPITX2 is a homeobox gene located in the human 4q25 locus and is commonly associated with atrial fibrillation (AF). Here, we generated two PITX2 knock-out human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 genome editing. The edited iPSCs maintained full pluripotency, normal karyotype and sponta-neous differentiation capability. This cell line provides a suitable model for investigating the physiopathology of PITX2 mutation in atrial fibrillation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfStem Cell Research-
dc.relation.isPartOfSTEM CELL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleGeneration of two PITX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorMun, Dasom-
dc.contributor.googleauthorKANG, JIYOUNG-
dc.contributor.googleauthorChun, Yumin-
dc.contributor.googleauthorPark, Da-Seul-
dc.contributor.googleauthorKim, Hyoeun-
dc.contributor.googleauthorYun, Nuri-
dc.contributor.googleauthorLee , Seung hyun-
dc.contributor.googleauthorJoung, Bo Young-
dc.identifier.doi10.1016/j.scr.2022.102940-
dc.relation.journalcodeJ02680-
dc.identifier.eissn1876-7753-
dc.identifier.pmid36260954-
dc.contributor.alternativeNameLee, Seung Hyun-
dc.contributor.affiliatedAuthorMun, Dasom-
dc.contributor.affiliatedAuthorKANG, JIYOUNG-
dc.contributor.affiliatedAuthorChun, Yumin-
dc.contributor.affiliatedAuthorPark, Da-Seul-
dc.contributor.affiliatedAuthorKim, Hyoeun-
dc.contributor.affiliatedAuthorYun, Nuri-
dc.contributor.affiliatedAuthorLee , Seung hyun-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.identifier.scopusid2-s2.0-85139866004-
dc.identifier.wosid000876544900006-
dc.citation.volume65-
dc.identifier.bibliographicCitationStem Cell Research, Vol.65, 2022-12-
dc.identifier.rimsid76797-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalClass1-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryCell & Tissue Engineering-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.identifier.articleno102940-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
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