0 310

Cited 2 times in

Vessel-specific plaque features on coronary computed tomography angiography among patients of varying atherosclerotic cardiovascular disease risk

Authors
 A Maxim Bax  ;  Yeonyee E Yoon  ;  Umberto Gianni  ;  Alexander R van Rosendael  ;  Yao Lu  ;  Xiaoyue Ma  ;  Benjamin P Goebel  ;  Sara W Tantawy  ;  Daniele Andreini  ;  Matthew J Budoff  ;  Filippo Cademartiri  ;  Kavitha Chinnaiyan  ;  Jung Hyun Choi  ;  Edoardo Conte  ;  Pedro de Araújo Gonçalves  ;  Ilan Gottlieb  ;  Martin Hadamitzky  ;  Jonathon A Leipsic  ;  Erica Maffei  ;  Gianluca Pontone  ;  Sanghoon Shin  ;  Yong Jin Kim  ;  Byoung Kwon Lee  ;  Eun Ju Chun  ;  Ji Min Sung  ;  Sang Eun Lee  ;  Daniel S Berman  ;  Jagat Narula  ;  Fay Y Lin  ;  Hyuk Jae Chang  ;  Leslee J Shaw 
Citation
 EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol.23(9) : 1171-1179, 2022-08 
Journal Title
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
ISSN
 2047-2404 
Issue Date
2022-08
MeSH
Aged ; Atherosclerosis* ; Cardiovascular Diseases* ; Computed Tomography Angiography ; Coronary Angiography / methods ; Coronary Artery Disease* / diagnostic imaging ; Coronary Vessels ; Female ; Humans ; Male ; Middle Aged ; Plaque, Atherosclerotic* / diagnostic imaging ; Prospective Studies
Keywords
atherosclerotic cardiovascular disease ; coronary arteries ; coronary artery disease ; coronary computed tomography angiography ; plaque composition ; plaque distribution
Abstract
Aims: The relationship between AtheroSclerotic CardioVascular Disease (ASCVD) risk and vessel-specific plaque evaluation using coronary computed tomography angiography (CCTA), focusing on plaque extent and composition, has not been examined. To evaluate differences in quantified plaque characteristics (using CCTA) between the three major coronary arteries [left anterior descending (LAD), right coronary (RCA), and left circumflex (LCx)] among subgroups of patients with varying ASCVD risk.

Methods and results: Patients were included from a prospective, international registry of consecutive patients who underwent CCTA for evaluation of coronary artery disease. ASCVD risk groups were <7.5% (low), 7.5-20% (intermediate), and ≥20% (high). Among the ASCVD risk groups, the three coronary arteries were compared regarding quantified plaque volume and composition. Whole-heart plaque quantification was performed in 1340 patients (age 60 ± 9 years, 58% men). Across low, intermediate, and high ASCVD risk patients, the volume of plaque increased proportionally but was least in the LCx (7.4, 9.0, and 25.3 mm3, respectively) as compared with the RCA (19.3, 32.6, and 67.0 mm3, respectively, all P ≤ 0.006) and LAD (39.9, 60.8, and 93.3 mm3, respectively, all P < 0.001). In each ASCVD risk group, the composition of plaque in the LCx exhibited the least necrotic core and fibrofatty plaque (P < 0.05 vs. LAD and RCA).

Conclusion: Among patients with varying risk of ASCVD, plaque in the LCx is decidedly less and is comprised of less non-calcified plaque supporting prior evidence of the lower rates of acute coronary events in this vessel.
Full Text
https://academic.oup.com/ehjcimaging/article/23/9/1171/6543558
DOI
10.1093/ehjci/jeac029
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Sung, Ji Min(성지민)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Lee, Sang-Eun(이상은) ORCID logo https://orcid.org/0000-0001-6645-4038
Lee, Hyang Kyu(이향규) ORCID logo https://orcid.org/0000-0002-0821-6020
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193303
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links