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Impact of COVID-19 Pandemic on Management and Outcomes in Patients with Septic Shock in the Emergency Department

 Daun Jeong  ;  Gun Tak Lee  ;  Jong Eun Park  ;  Tae Gun Shin  ;  Kyunga Kim  ;  Doeun Jang  ;  Won Young Kim  ;  You Hwan Jo  ;  Sung Phil Chung  ;  Jin Ho Beom  ;  Sung-Hyuk Choi  ;  Woon Yong Kwon  ;  Gil Joon Suh  ;  Byuk Sung Ko  ;  Kap Su Han  ;  Jong Hwan Shin  ;  Hanjin Cho  ;  Korean Shock Society KoSS Investigators  ;  Sung Yeon Hwang 
 JOURNAL OF PERSONALIZED MEDICINE, Vol.12(11) : 1803, 2022-11 
Journal Title
Issue Date
COVID-19 ; mortality ; resuscitation ; sepsis bundle ; septic shock
This study aimed to determine the impact of modifications in emergency department (ED) practices caused by the coronavirus disease 2019 (COVID-19) pandemic on the clinical outcomes and management of patients with septic shock. We performed a retrospective study. Patients with septic shock who presented to the ED between 1 January 2018 and 19 January 2020 were allocated to the pre-COVID-19 group, whereas those who presented between 20 January 2020 and 31 December 2020 were assigned to the post-COVID-19 group. We used propensity score matching to compare the sepsis-related interventions and clinical outcomes. The primary outcome measure was in-hospital mortality. Of the 3697 patients included, 2254 were classified as pre-COVID-19 and 1143 as post-COVID-19. A total of 1140 propensity score-matched pairings were created. Overall, the in-hospital mortality rate was 25.5%, with no statistical difference between the pre- and post-COVID-19 groups (p = 0.92). In a matched cohort, the post-COVID-19 group had delayed lactate measurement, blood culture test, and infection source control (all p < 0.05). There was no significant difference in time to antibiotics (p = 0.19) or vasopressor administration (p = 0.09) between the groups. Although sepsis-related interventions were delayed during the COVID-19 pandemic, there was no significant difference in the in-hospital mortality between the pre- and post-COVID-19 groups.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Beom, Jin Ho(범진호) ORCID logo https://orcid.org/0000-0002-2805-257X
Chung, Sung Phil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
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