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Triglyceride-glucose index is associated with gastroesophageal reflux disease and erosive reflux disease: a health checkup cohort study

 Young Min Kim  ;  Yuna Kim  ;  Jie-Hyun Kim  ;  Jong Suk Park  ;  Su Jung Baik  ;  Jaeyoung Chun  ;  Young Hoon Youn  ;  Hyojin Park 
 SCIENTIFIC REPORTS, Vol.12(1) : 20959, 2022-12 
Journal Title
Issue Date
Biomarkers ; Blood Glucose / metabolism ; Cohort Studies ; Gastroesophageal Reflux* ; Glucose ; Humans ; Insulin Resistance* ; Metabolic Syndrome* / epidemiology ; Retrospective Studies ; Risk Factors ; Triglycerides
The triglyceride-glucose (TyG) index was proposed as a useful marker of metabolic syndrome. Insulin resistance, the main mechanism underlying metabolic syndrome, is related to gastroesophageal reflux disease (GERD). This study aimed to elucidate the association between the TyG index and GERD/erosive reflux disease (ERD). We retrospectively reviewed the electronic medical records of patients who underwent gastroduodenoscopy at a checkup center. The calculation of TyG index used following formula: ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). We divided the patients into four groups according to the TyG index quartile (Q). We evaluated the relationship between the alteration of the TyG index and GERD in patients who received health checkups two times. Among the 52,605 enrolled patients, 3073 (5.8%) and 434 (0.8%) were diagnosed with GERD and ERD, respectively. The odds ratios (ORs) for GERD in the TyG index progressively increased across quartiles (P < 0.001): Q2 (OR = 2.477), Q3 (OR = 3.013), and Q4 (OR = 4.027) compared with Q1, which was used as a reference, respectively. Those for ERD also progressively increased across quartiles (P < 0.001): Q2 (OR = 4.264), Q3 (OR = 4.841), and Q4 (OR = 7.390) compared with Q1, respectively. Moreover, the degree of TyG index increase during the first and second tests in the GERD group was more prominent than in the control group (P = 0.001). In conclusion, the higher TyG index was significantly associated with GERD. The TyG index may be a novel predictive biomarker of GERD and ERD.
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6. Others (기타) > Gangnam Severance Hospital Health Promotion Center(강남세브란스병원 체크업) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Min(김영민)
Kim, Yuna(김윤아)
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Baik, Su Jung(백수정) ORCID logo https://orcid.org/0000-0002-3790-7701
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
Chun, Jaeyoung(천재영) ORCID logo https://orcid.org/0000-0002-4212-0380
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