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Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models

DC Field Value Language
dc.contributor.author김성희-
dc.contributor.author남기택-
dc.contributor.author박인호-
dc.contributor.author서준영-
dc.contributor.author신전수-
dc.date.accessioned2023-03-03T02:50:10Z-
dc.date.available2023-03-03T02:50:10Z-
dc.date.issued2022-11-
dc.identifier.issn1754-8403-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192908-
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, causes life-threatening disease. This novel coronavirus enters host cells via the respiratory tract, promoting the formation of severe pulmonary lesions and systemic disease. Few animal models can simulate the clinical signs and pathology of COVID-19 patients. Diverse preclinical studies using K18-hACE2 mice and Syrian golden hamsters, which are highly permissive to SARS-CoV-2 in the respiratory tract, are emerging; however, the systemic pathogenesis and cellular tropism of these models remain obscure. We intranasally infected K18-hACE2 mice and Syrian golden hamsters with SARS-CoV-2, and compared the clinical features, pathogenesis, cellular tropism and infiltrated immune-cell subsets. In K18-hACE2 mice, SARS-CoV-2 persistently replicated in alveolar cells and caused pulmonary and extrapulmonary disease, resulting in fatal outcomes. Conversely, in Syrian golden hamsters, transient SARS-CoV-2 infection in bronchial cells caused reversible pulmonary disease, without mortality. Our findings provide comprehensive insights into the pathogenic spectrum of COVID-19 using preclinical models.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherCompany of Biologists Ltd-
dc.relation.isPartOfDISEASE MODELS & MECHANISMS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCOVID-19*-
dc.subject.MESHCricetinae-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHLung / pathology-
dc.subject.MESHMesocricetus-
dc.subject.MESHMice-
dc.subject.MESHMice, Transgenic-
dc.subject.MESHSARS-CoV-2-
dc.titleComparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorHaengdueng Jeong-
dc.contributor.googleauthorYoun Woo Lee-
dc.contributor.googleauthorIn Ho Park-
dc.contributor.googleauthorHyuna Noh-
dc.contributor.googleauthorSung-Hee Kim-
dc.contributor.googleauthorJiseon Kim-
dc.contributor.googleauthorDonghun Jeon-
dc.contributor.googleauthorHui Jeong Jang-
dc.contributor.googleauthorJooyeon Oh-
dc.contributor.googleauthorDain On-
dc.contributor.googleauthorChanyang Uhm-
dc.contributor.googleauthorKyungrae Cho-
dc.contributor.googleauthorHeeju Oh-
dc.contributor.googleauthorSuhyeon Yoon-
dc.contributor.googleauthorJung Seon Seo-
dc.contributor.googleauthorJeong Jin Kim-
dc.contributor.googleauthorSang-Hyuk Seok-
dc.contributor.googleauthorYu Jin Lee-
dc.contributor.googleauthorSeung-Min Hong-
dc.contributor.googleauthorSe-Hee An-
dc.contributor.googleauthorSeo Yeon Kim-
dc.contributor.googleauthorYoung Been Kim-
dc.contributor.googleauthorJi-Yeon Hwang-
dc.contributor.googleauthorHyo-Jung Lee-
dc.contributor.googleauthorHong Bin Kim-
dc.contributor.googleauthorDae Gwin Jeong-
dc.contributor.googleauthorDaesub Song-
dc.contributor.googleauthorManki Song-
dc.contributor.googleauthorMan-Seong Park-
dc.contributor.googleauthorKang-Seuk Choi-
dc.contributor.googleauthorJun Won Park-
dc.contributor.googleauthorJun-Young Seo-
dc.contributor.googleauthorJun-Won Yun-
dc.contributor.googleauthorJeon-Soo Shin-
dc.contributor.googleauthorHo-Young Lee-
dc.contributor.googleauthorKi Taek Nam-
dc.contributor.googleauthorJe Kyung Seong-
dc.identifier.doi10.1242/dmm.049632-
dc.contributor.localIdA06017-
dc.contributor.localIdA01243-
dc.contributor.localIdA01631-
dc.contributor.localIdA01911-
dc.contributor.localIdA02144-
dc.relation.journalcodeJ04375-
dc.identifier.eissn1754-8411-
dc.identifier.pmid36222118-
dc.subject.keywordK18-hACE2 mice-
dc.subject.keywordSARS-CoV-2-
dc.subject.keywordSyrian golden hamster-
dc.contributor.alternativeNameKim, Sung-Hee-
dc.contributor.affiliatedAuthor김성희-
dc.contributor.affiliatedAuthor남기택-
dc.contributor.affiliatedAuthor박인호-
dc.contributor.affiliatedAuthor서준영-
dc.contributor.affiliatedAuthor신전수-
dc.citation.volume15-
dc.citation.number11-
dc.citation.startPagedmm049632-
dc.identifier.bibliographicCitationDISEASE MODELS & MECHANISMS, Vol.15(11) : dmm049632, 2022-11-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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