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Effects of meibomian gland dysfunction and aqueous deficiency on friction-related disease

 Hyunmin Ahn  ;  Yong Woo Ji  ;  Ikhyun Jun  ;  Tae-Im Kim  ;  Hyung Keun Lee  ;  Kyoung Yul Seo 
 OCULAR SURFACE, Vol.26 : 295-299, 2022-10 
Journal Title
Issue Date
Cross-Sectional Studies ; Dry Eye Syndromes* ; Friction ; Humans ; Male ; Meibomian Gland Dysfunction* / diagnosis ; Meibomian Glands ; Tears
Dry eye ; Friction-related disease ; Keratograph 5 M ; LipiView ; Meibomian gland dysfunction
Purpose: To evaluate the effects of meibomian gland dysfunction (MGD) and aqueous deficiency (AD) on friction-related disease (FRD).

Methods: Cross-sectional comparative study. This study included 550 eyes (550 patients) with dry eye disease (DED). The DED subtype and dynamic tear-film parameters by automated assessments were investigated for the analysis of FRD (superior limbic keratoconjunctivitis, conjunctivochalasis, and lid wiper epitheliopathy).

Results: Patients with FRD had a higher proportion of moderate-to-severe MGD and AD (p < 0.001 and p < 0.001, respectively). The dropout rate of the meibomian gland was higher (30.5 ± 31.8 and 14.1 ± 25.0%, p < 0.001), tear meniscus height (TMH) was lower (227.8 ± 60.4 and 241.7 ± 55.6 μm, p = 0.008), and he first non-invasive keratographic tear break-up time (NIKBUT-1) was shorter (5.9 ± 3.5 and 7.3 ± 3.7 s, p < 0.001) in patients with FRD than in those without FRD. In the logistic regression analysis with clinical manifestation, both moderate-to-severe MGD and AD were associated with FRD (odds ratios [OR] 12.27, 95% confidence interval [CI] 7.72-19.50, and 2.31, 95% CI 1.43-3.71], p < 0.001 and p < 0.001, respectively). The dropout rate was positively associated with FRD (OR 1.017, 95% CI 1.010-1.023, p < 0.001). TMH and NIKBUT-1 were negatively associated with FRD (OR 0.995, 95% CI 0.991-0.999, and 0.90, 95% CI 0.85-0.95, p = 0.039 and p < 0.001, respectively).

Conclusions: This study showed that FRD was highly associated with MGD and meibomian gland dropout rate, suggesting that FRD may be mainly affected by lipid components. AD and TMH also had a good but relatively lower association with FRD, compared to MGD and meibomian gland dropout rate.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Ahn, Hyunmin(안현민)
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
Jun, Ik Hyun(전익현) ORCID logo https://orcid.org/0000-0002-2160-1679
Ji, Yong Woo(지용우) ORCID logo https://orcid.org/0000-0002-7211-6278
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