A facial scanner and three-dimensional computed tomography (CT) were used to evaluate the three-dimensional change in lip asymmetry before and after two-jaw surgery for 22 patients with facial asymmetry (menton deviation > 3 mm). We used the labrale superius (Ls), deviated/non-deviated-side cheilions (Ch-D/Ch-ND), and labrale inferius (Li) to construct the upper and lower lip planes to evaluate the lip asymmetry. A correlation analysis was performed to determine the factors related to the vertical change in the cheilions (ΔChZ-D/ND). In the transverse axis, Ch-D and Li moved to improve the asymmetry after surgery. All landmarks, except the Ls, moved backward in the anteroposterior axis. In the vertical axis, significant upward movement was observed in all hard tissue landmarks; however, there were no significant changes in the soft tissue. In the lip plane, the difference in the height of Ch-D and Ch-ND was significantly reduced (1.38 mm vs. 0.72 mm). In the anteroposterior axis, the ΔChZ-D/ND showed significant correlations with the mandibular setback. In the vertical axis, the ΔCh-ND showed significant correlations with the maxillary impaction of the non-deviated side. The improvement in lip asymmetry post-surgery was mainly achieved by the movement of the lower lip and Ch-D rather than the upper lip and Ch-ND