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Serum uric acid level predicts the progression of amyotrophic lateral sclerosis following treatment with edaravone

Authors
 Hee Jo Han  ;  Ha Young Shin  ;  Young-Chul Choi  ;  Seung Min Kim  ;  Seung Woo Kim 
Citation
 REDOX REPORT, Vol.27(1) : 79-84, 2022-12 
Journal Title
REDOX REPORT
ISSN
 1351-0002 
Issue Date
2022-12
MeSH
Amyotrophic Lateral Sclerosis* / drug therapy ; Edaravone / therapeutic use ; Humans ; Oxidative Stress ; Uric Acid*
Keywords
ALS ; Uric acid ; amyotrophic lateral sclerosis ; edaravone ; motor neuron ; oxidative stress ; prognosis ; radical scavenger
Abstract
Introduction: Uric acid and edaravone might exert a neuroprotective effect in amyotrophic lateral sclerosis (ALS) by reducing oxidative stress. We analyzed whether the treatment effect of edaravone is pronounced in patients whose uric acid level increased after the treatment with edaravone.

Materials and methods: Forty patients with ALS who underwent treatment with edaravone were included. Baseline uric acid level and the rate of decline in uric acid after edaravone treatment were recorded. The rate of change of ALS functional rating scale-revised (ΔALSFRS-R/month) was calculated based on baseline ALSFRS-R score and ALSFRS-R score 6-24 weeks after the treatment.

Results: The serum uric acid levels decreased after treatment in 26 (65%) patients and increased in 12 (30%) patients. The ΔALSFRS-R/month was significantly faster in patients whose uric acid decreased (median 1.5 [Q1-Q3, 0.7-3.1]) than in patients whose uric acid increased (0.2 [0-1.0], p = 0.021). A high baseline uric acid level and low rate of decline in uric acid was associated with slower disease progression after adjusting for age, initial symptoms, and riluzole administration (p = 0.030 and p = 0.041, respectively).

Discussion: High baseline values and low rate of decline in uric acid may predict slow disease progression in ALS patients treated with edaravone.
Files in This Item:
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DOI
10.1080/13510002.2022.2051964
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Min(김승민) ORCID logo https://orcid.org/0000-0002-4384-9640
Kim, Seung Woo(김승우) ORCID logo https://orcid.org/0000-0002-5621-0811
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192367
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