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Intermittent Fasting Is Associated With a Decreased Risk of Age-Related Macular Degeneration

Authors
 Eun Young Choi  ;  Min Kim  ;  Christopher Seungkyu Lee  ;  Suk Ho Byeon  ;  Sung Soo Kim  ;  Minyoung Lee 
Citation
 AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.243 : 1-9, 2022-11 
Journal Title
AMERICAN JOURNAL OF OPHTHALMOLOGY
ISSN
 0002-9394 
Issue Date
2022-11
MeSH
Aged ; Cross-Sectional Studies ; Fasting* ; Humans ; Lipoproteins, HDL ; Macular Degeneration* / diagnosis ; Macular Degeneration* / epidemiology ; Macular Degeneration* / etiology ; Nutrition Surveys ; Obesity / complications ; Obesity / epidemiology ; Prevalence
Keywords
Age-related macular degeneration ; Breakfast skipping ; Intermittent fasting ; Korean National Health and Nutrition Examination Survey
Abstract
Purpose: To investigate the association between intermittent fasting and age-related macular degeneration (AMD) in the general older adult population.

Design: A cross-sectional study using a population-based, government-led survey data, Korean National Health and Nutrition Examination Survey (KNHANES).

Methods: A total of 4504 individuals aged ≥55 years with comprehensive data including meal frequency and fundus photography were selected using the KNHANES 2015-2018 database. Participants were divided into 2 groups based on breakfast frequency per week; intermittent fasting (nearly 0 time/week) and nonfasting (5-7 times/week) groups. Multiple logistic regression analysis was performed to determine the risk factors for AMD identified by fundus photography.

Results: AMD was identified in 25.1% of total participants. The intermittent fasting group had a decreased risk of AMD compared with the nonfasting group (adjusted odds ratio [aOR] 0.413, 95% CI 0.203-0.841), especially in individuals with a younger age (<70 years, aOR 0.357, 95% CI 0.153-0.833), obesity (aOR 0.663, 95% CI 0.424-1.037), and urban residence (aOR 0.437, 95% CI 0.248-0.769). Increased age (aOR 1.058, 95% CI 1.041-1.076) and serum high-density lipoprotein levels (aOR 1.011, 95% CI 1.002-1.021) were also independent risk factors for AMD.

Conclusions: Using the population-based survey data, we demonstrated that intermittent fasting by skipping breakfast was significantly associated with a reduced risk of AMD in a representative older adult population, especially in individuals with age <70 years, obesity, and urban residence.
Full Text
https://www.sciencedirect.com/science/article/pii/S0002939422002550?via%3Dihub
DOI
10.1016/j.ajo.2022.06.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Choi, Eun Young(최은영) ORCID logo https://orcid.org/0000-0002-1668-6452
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192292
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