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Nephron-Sparing Approaches in Upper Tract Urothelial Carcinoma: Current and Future Strategies

 Won Sik Ham  ;  Jee Soo Park  ;  Won Sik Jang  ;  Jongchan Kim 
 BIOMEDICINES, Vol.10(9) : 2223, 2022-09 
Journal Title
Issue Date
kidney function ; nephron-sparing ; upper urinary tract ; urothelial carcinoma
Upper tract urothelial carcinoma (UTUC) is a relatively rare cancer, and much of the approach to treatment has been derived from strategies employed in treating bladder cancer. Radical nephroureterectomy (RNU) is regarded as the gold standard treatment for UTUC. However, due to potential complications, such as renal function impairment, that can affect oncologic outcomes, the demand for nephron-sparing treatment to effectively treat cancer while preserving renal function has increased. As a result, various treatment methods for low-grade, low-volume UTUC, such as segmental ureterectomy, endoscopic resection, and intraluminal therapy, have been attempted and reported. Although these treatment modalities have exhibited acceptable oncological results, further studies are required. In the future, the introduction of new technologies, such as improved diagnostic and surgical equipment, and new drug delivery systems, could enhance the effectiveness of nephron-sparing strategies in the treatment of UTUC. Additionally, understanding the biological and genetic characteristics of UTUC that distinguish it from those of bladder cancer will also aid in establishing strategies for nephron-sparing.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Chan(김종찬) ORCID logo https://orcid.org/0000-0002-0022-6689
Park, Jee Soo(박지수) ORCID logo https://orcid.org/0000-0001-9976-6599
Jang, Won Sik(장원식) ORCID logo https://orcid.org/0000-0002-9082-0381
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
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