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Elevated gamma-glutamyl transpeptidase level is associated with an increased risk of hip fracture in postmenopausal women

 Kyoung Jin Kim  ;  Namki Hong  ;  Min Heui Yu  ;  Seunghyun Lee  ;  Sungjae Shin  ;  Sin Gon Kim  ;  Yumie Rhee 
 SCIENTIFIC REPORTS, Vol.12(1) : 13947, 2022-08 
Journal Title
Issue Date
Female ; Hip Fractures* / epidemiology ; Hip Fractures* / etiology ; Humans ; Incidence ; Liver Function Tests ; Middle Aged ; Postmenopause ; Risk Factors ; gamma-Glutamyltransferase*
The aim of this study was to evaluate the association between gamma-glutamyl transferase (GGT) levels and the risk of hip fracture among middle-aged women by using the Korean National Health Insurance Service claims database from 2002 to 2015. After exclusion of those with any chronic liver disease, heavy alcohol consumption, any missing values required for our analysis, or GGT levels less than 1 or greater than 99 percentile, we classified subjects into three groups according to baseline GGT levels. A total of 127,141 women aged 50 years or older were included for analysis (GGT range: 8-106 U/L). During an average 12.1 years of follow-up, 2758 patients sustained hip fractures (2.17%). Compared with the group in the lowest tertile, the group in the highest tertile had the highest cumulative incidence of hip fracture. One log-unit increase in GGT was associated with a 17% increased risk of hip fracture. Subgroup analysis by BMI (≥ 25 vs. < 25 kg/m2), presence of diabetes, levels of other liver enzymes, and alcohol consumption level did not show significant effect modification. In summary, elevated baseline GGT level was associated with an increased risk of hip fracture in postmenopausal women, independent of alcohol consumption and chronic liver disease.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재)
Lee, Seunghyun(이승현)
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
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