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Pembrolizumab-induced Stevens-Johnson Syndrome with Severe Ocular Complications

Authors
 Soyoung Ryu  ;  Ikhyun Jun  ;  Tae-Im Kim  ;  Kyoung Yul Seo  ;  Eung Kweon Kim 
Citation
 OCULAR IMMUNOLOGY AND INFLAMMATION, Vol.30(6) : 1533-1535, 2022-08 
Journal Title
OCULAR IMMUNOLOGY AND INFLAMMATION
ISSN
 0927-3948 
Issue Date
2022-08
MeSH
Antibodies, Monoclonal, Humanized / adverse effects ; Humans ; Male ; Middle Aged ; Stevens-Johnson Syndrome* / diagnosis ; Stevens-Johnson Syndrome* / etiology
Keywords
Pembrolizumab ; Stevens–Johnson syndrome ; immune checkpoint inhibitors ; ocular manifestation ; severe ocular complications
Abstract
Purpose: To report a unique case of Stevens-Johnson syndrome (SJS) with severe ocular complications induced by pembrolizumab, an immune checkpoint inhibitor.

Case presentation: A 64-year-old man with urothelial cancer presented with bilateral corneal epithelial defect and conjunctival pseudo-membrane formation with erythematous patches on the four extremities, abdomen, and back. He had urothelial cancer with multifocal lesions in the renal pelvis and left ureter, and para-aortic metastatic lymph nodes. Accordingly, pembrolizumab treatment was planned. Generalized skin eruption occurred 4 days after the first cycle of pembrolizumab treatment, and ocular symptoms occurred 2 weeks after the first cycle. The patient's symptoms improved after cessation of pembrolizumab treatment and administration of steroids systemically.

Conclusions: Immune checkpoint inhibitors, including pembrolizumab, have been developed recently and are widely used in the treatment of various cancers. However, it should be noted that the drugs may cause adverse events such as SJS with severe ocular complications.
Full Text
https://www.tandfonline.com/doi/full/10.1080/09273948.2021.1896006
DOI
10.1080/09273948.2021.1896006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae-Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Jun, Ik Hyun(전익현) ORCID logo https://orcid.org/0000-0002-2160-1679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191884
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