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Medication-Naïve Blood Pressure and Incident Cancers: Analysis of 2 Nationwide Population-Based Databases

Authors
 Hidehiro Kaneko  ;  Yuichiro Yano  ;  Hyeok-Hee Lee  ;  Hokyou Lee  ;  Akira Okada  ;  Hidetaka Itoh  ;  Kojiro Morita  ;  Akira Fukui  ;  Katsuhito Fujiu  ;  Yuta Suzuki  ;  Satoshi Matsuoka  ;  Sunao Nakamura  ;  Nobuaki Michihata  ;  Taisuke Jo  ;  Norifumi Takeda  ;  Hiroyuki Morita  ;  Takashi Yokoo  ;  Akira Nishiyama  ;  Koichi Node  ;  Anthony J Viera  ;  Paul Muntner  ;  Suzanne Oparil  ;  Hyeon Chang Kim  ;  Hideo Yasunaga  ;  Issei Komuro 
Citation
 AMERICAN JOURNAL OF HYPERTENSION, Vol.35(8) : 731-739, 2022-08 
Journal Title
AMERICAN JOURNAL OF HYPERTENSION
ISSN
 0895-7061 
Issue Date
2022-08
MeSH
Adult ; Antihypertensive Agents / adverse effects ; Blood Pressure / physiology ; Colorectal Neoplasms* / diagnosis ; Colorectal Neoplasms* / epidemiology ; Female ; Humans ; Hypertension* / complications ; Hypertension* / diagnosis ; Hypertension* / epidemiology ; Incidence ; Kidney Neoplasms* / complications ; Kidney Neoplasms* / epidemiology ; Male ; Middle Aged ; Risk Factors ; Stomach Neoplasms* / complications ; Stomach Neoplasms* / drug therapy
Keywords
blood pressure ; cancer ; epidemiology ; hypertension
Abstract
Background: Results of preceding studies on the relationship between blood pressure (BP) and cancers have been confounded due to individuals taking antihypertensive medications or shared risk factors. We assessed whether medication-naïve high BP is a risk factor for incident cancers.

Methods: This retrospective observational study included 1,388,331 individuals without a prior history of cancer and not taking antihypertensive medications enrolled in the JMDC Claims Database between 2005 and 2018. The primary outcome was 16 cancers.

Results: The median [interquartile range] age was 45 [40-52] years and 56.2% were men. Mean systolic BP (SBP) and diastolic BP (DBP) were 117.7 ± 15.8 and 72.8 ± 11.6 mm Hg. Multivariate Cox regression analysis demonstrated that SBP per 1-SD was associated with a higher incidence of thyroid (hazard ratio [HR]: 1.09, 95% confidence interval [CI]: 1.03-1.16), esophageal (HR: 1.15, 95% CI: 1.07-1.24), colorectal (HR: 1.04, 95% CI: 1.01-1.07), liver (HR: 1.11, 95% CI: 1.03-1.20), and kidney (HR: 1.22, 95% CI: 1.14-1.31) cancers, but with a lower incidence of stomach cancer (HR: 0.94, 95% CI: 0.91-0.98). These associations remained significant after adjustment for multiple testing. DBP was associated with higher incidences of thyroid, esophageal, colorectal, kidney, and corpus uteri cancers, but with a lower incidence of stomach cancer. The associations between SBP and incidences of thyroid, esophageal, colorectal, liver, and kidney cancers were confirmed in the Korean National Health Insurance Service database.

Conclusions: Medication-naïve BP was associated with higher incidences of thyroid, esophageal, colorectal, liver, and kidney cancers. Uncovering the underlying mechanisms for our results may help identify novel therapeutic approach for hypertension and cancer.
Full Text
https://academic.oup.com/ajh/article/35/8/731/6580567?login=true
DOI
10.1093/ajh/hpac054
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Lee, Hyeok-Hee(이혁희)
Lee, Hokyou(이호규) ORCID logo https://orcid.org/0000-0002-5034-8422
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191774
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