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Impact of pancreatic fat on the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis

Authors
 Chan Hyuk Park  ;  Moon Jae Chung  ;  Da Hae Park  ;  Seonjeong Min  ;  Se Woo Park 
Citation
 SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol.36(8) : 5734-5742, 2022-08 
Journal Title
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
ISSN
 0930-2794 
Issue Date
2022-08
MeSH
Acute Disease ; Catheterization / methods ; Cholangiopancreatography, Endoscopic Retrograde* / adverse effects ; Cholangiopancreatography, Endoscopic Retrograde* / methods ; Female ; Humans ; Pancreas ; Pancreatitis* / etiology ; Risk Factors
Keywords
Computed tomography ; Endoscopic retrograde cholangiopancreatography ; Fatty pancreas ; Pancreatitis
Abstract
Background and study aims: Fatty pancreas is a potential risk factor for acute pancreatitis; however, whether it is also a risk factor for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) has not been evaluated. We aimed to determine the impact of fatty pancreas on the development of PEP.

Methods: We analyzed the data of patients who underwent abdominal computed tomography (CT) scan and sequential therapeutic endoscopic retrograde cholangiopancreatography (ERCP). Fatty change in the pancreas was evaluated based on pancreatic attenuation of unenhanced image on CT scan. The risk of fatty pancreas for the development of PEP was evaluated using a logistic regression model.

Results: Of a total of 858 patients included in the study, 354 (41.3%) had fatty pancreas, while 504 (58.7%) did not have fatty pancreas. PEP developed in 28 patients (7.9%) in the fatty pancreas group and in 13 patients (2.6%) in the no fatty pancreas group. Fatty pancreas was significantly associated with the development of PEP (odds ratio [OR] [95% confidence interval [CI]] 2.38 [1.16-4.87]). A history of acute pancreatitis, female sex, difficult cannulation, and endoscopic papillary balloon dilation were also risk factors for the development of PEP. The risk for moderate-to-severe PEP development tended to be higher in the fatty pancreas group than in the no fatty pancreas group (OR [95% CI] 5.61 [0.63-49.62]).

Conclusions: Fatty pancreas is a significant risk factor for the development of PEP. Clinicians need to be aware of the risk of fatty pancreas for the development of PEP prior to performing ERCP.
Full Text
https://link.springer.com/article/10.1007/s00464-022-09070-8
DOI
10.1007/s00464-002-09070-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191761
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