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Contracted thalamic shape is associated with early development of levodopa-induced dyskinesia in Parkinson's disease

Authors
 Han Soo Yoo  ;  Eun-Chong Lee  ;  Seok Jong Chung  ;  Byoung Seok Ye  ;  Young H Sohn  ;  Joon-Kyung Seong  ;  Phil Hyu Lee 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 12631, 2022-07 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-07
MeSH
Antiparkinson Agents / adverse effects ; Dyskinesia, Drug-Induced* / diagnostic imaging ; Dyskinesia, Drug-Induced* / etiology ; Humans ; Levodopa / adverse effects ; Parkinson Disease* / complications ; Parkinson Disease* / drug therapy ; Thalamus / diagnostic imaging
Abstract
Levodopa-induced dyskinesia (LID), a long-term motor complication in Parkinson's disease (PD), is attributable to both presynaptic and postsynaptic mechanisms. However, no studies have evaluated the baseline structural changes associated with LID at a subcortical level in PD. A total of 116 right-handed PD patients were recruited and based on the LID latency of 5 years, we classified patients into those vulnerable to LID (PD-vLID, n = 49) and those resistant to LID (PD-rLID, n = 67). After adjusting for covariates including dopamine transporter (DAT) availability of the posterior putamen, we compared the subcortical shape between the groups and investigated its association with the onset of LID. The PD-vLID group had lower DAT availability in the posterior putamen, higher parkinsonian motor deficits, and faster increment in levodopa equivalent dose than the PD-rLID group. The PD-vLID group had significant inward deformation in the right thalamus compared to the PD-rLID group. Inward deformation in the thalamus was associated with an earlier onset of LID at baseline. This study suggests that independent of presynaptic dopamine depletion, the thalamus is a major neural substrate for LID and that a contracted thalamic shape at baseline is closely associated with an early development of LID.
Files in This Item:
T202204573.pdf Download
DOI
10.1038/s41598-022-16747-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191718
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