Cited 9 times in
Ultrafast dynamic contrast-enhanced breast MRI: association with pathologic complete response in neoadjuvant treatment of breast cancer
DC Field | Value | Language |
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dc.contributor.author | 김민정 | - |
dc.contributor.author | 박영진 | - |
dc.contributor.author | 윤정현 | - |
dc.date.accessioned | 2022-12-22T02:40:06Z | - |
dc.date.available | 2022-12-22T02:40:06Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191656 | - |
dc.description.abstract | Objectives: The purpose of this study was to investigate whether pretreatment kinetic features from ultrafast DCE-MRI are associated with pathological complete response (pCR) in patients with invasive breast cancer and according to immunohistochemistry (IHC) subtype. Methods: Between August 2018 and June 2019, 256 consecutive breast cancer patients (mean age, 50.2 years; range, 25-86 years) who underwent both ultrafast and conventional DCE-MRI and surgery following neoadjuvant chemotherapy were included. DCE-MRI kinetic features were obtained from pretreatment MRI data. Time-to-enhancement, maximal slope (MS), and volumes at U1 and U2 (U1, time point at which the lesion starts to enhance; U2, subsequent time point after U1) were derived from ultrafast MRI. Logistic regression analysis was performed to identify factors associated with pCR. Results: Overall, 41.4% of all patients achieved pCR. None of the kinetic features was associated with pCR when including all cancers. Among ultrafast DCE-MRI kinetic features, a lower MS (OR, 0.982; p = 0.040) was associated with pCR at univariable analysis in hormone receptor (HR)-positive cancers. In triple-negative cancers, a higher volume ratio U1/U2 was associated with pCR at univariable (OR, 11.787; p = 0.006) and multivariable analysis (OR, 14.811; p = 0.005). Among conventional DCE-MRI kinetic features, a lower peak enhancement (OR, 0.993; p = 0.031) and a lower percentage of washout (OR, 0.904; p = 0.039) was associated with pCR only in HR-positive cancers at univariable analysis. Conclusions: A higher volume ratio of U1/U2 derived from ultrafast DCE-MRI was independently associated with pCR in triple-negative invasive breast cancer. Key points: • The ratio of tumor volumes obtained at the first (U1) and second time points (U2) of enhancement was independently associated with pCR in triple-negative invasive breast cancers. • Ultrafast MRI has the potential to improve accuracy in predicting treatment response and personalizing therapy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Breast / pathology | - |
dc.subject.MESH | Breast Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Breast Neoplasms* / pathology | - |
dc.subject.MESH | Breast Neoplasms* / therapy | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Triple Negative Breast Neoplasms* / pathology | - |
dc.title | Ultrafast dynamic contrast-enhanced breast MRI: association with pathologic complete response in neoadjuvant treatment of breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Ji Hee Kim | - |
dc.contributor.googleauthor | Vivian Youngjean Park | - |
dc.contributor.googleauthor | Hye Jung Shin | - |
dc.contributor.googleauthor | Min Jung Kim | - |
dc.contributor.googleauthor | Jung Hyun Yoon | - |
dc.identifier.doi | 10.1007/s00330-021-08530-4 | - |
dc.contributor.localId | A00473 | - |
dc.contributor.localId | A01572 | - |
dc.contributor.localId | A02595 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 35064805 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00330-021-08530-4 | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Kinetics | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Neoadjuvant therapy | - |
dc.contributor.alternativeName | Kim, Min Jung | - |
dc.contributor.affiliatedAuthor | 김민정 | - |
dc.contributor.affiliatedAuthor | 박영진 | - |
dc.contributor.affiliatedAuthor | 윤정현 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 4823 | - |
dc.citation.endPage | 4833 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, Vol.32(7) : 4823-4833, 2022-07 | - |
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