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Complications, treatments, and visual prognosis of choroidal osteomas

Authors
 Hyo Jin Seong  ;  Yong Joon Kim  ;  Eun Young Choi  ;  Junwon Lee  ;  Suk Ho Byeon  ;  Sung Soo Kim  ;  Hyoung Jun Koh  ;  Sung Chul Lee  ;  Christopher Seungkyu Lee 
Citation
 GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.260(5) : 1713-1721, 2022-05 
Journal Title
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
ISSN
 0721-832X 
Issue Date
2022-05
MeSH
Angiogenesis Inhibitors / therapeutic use ; Choroidal Neovascularization* / drug therapy ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Osteoma* / complications ; Osteoma* / diagnosis ; Osteoma* / drug therapy ; Prognosis ; Ranibizumab ; Retrospective Studies ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A ; Visual Acuity
Keywords
Choroidal neovascularization ; Choroidal osteoma ; Intravitreal injection ; Photodynamic therapy ; Subretinal fluid
Abstract
Purpose: This study aims to report complications, treatments, and visual prognosis of choroidal osteoma.

Methods: We retrospectively reviewed electronic medical records and multimodal images of 41 patients with choroidal osteoma.

Results: Visually significant complications included choroidal neovascularization (CNV) in 21 (47.7%) eyes and subretinal fluid (SRF) without CNV in 14 (31.8%) eyes. The most common treatment was intravitreal anti-vascular endothelial growth factor (VEGF) injection: 13 (61.9%) eyes with CNV received an average of 6.3 injections, and 6 (42.9%) eyes with SRF but without CNV received 1.8 injections. As the first-line treatment, intravitreal anti-VEGF injection induced complete or partial remission in 93.4% of eyes with CNV and 57.1% of eyes with SRF. The probability of legally low vision estimated at 3 and at 5 years was 29.1% and 34.2%, respectively. The presence of CNV and outer retinal tubulation (ORT) was independent risk factors for vision loss (adjusted odds ratio, 8.08 and 6.94, respectively).

Conclusions: The development of CNV and ORT was strong risk factors for visual impairment. Due to the frequent recurrence of complications and poor visual prognosis, regular check-ups and appropriate treatment choices are warranted.
Full Text
https://link.springer.com/article/10.1007/s00417-021-05487-4
DOI
10.1007/s00417-021-05487-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Kim, Yong Joon(김용준)
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Jun Won(이준원) ORCID logo https://orcid.org/0000-0003-0543-7132
Choi, Eun Young(최은영) ORCID logo https://orcid.org/0000-0002-1668-6452
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191385
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