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An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis

Authors
 Jun Oh Lee  ;  Geun Dong Lee  ;  Hyeong Ryul Kim  ;  Dong Kwan Kim  ;  Seung-Il Park  ;  Jong Ho Cho  ;  Hong Kwan Kim  ;  Yong Soo Choi  ;  Jhingook Kim  ;  Young Mog Shim  ;  Samina Park  ;  In Kyu Park  ;  Chang Hyun Kang  ;  Young Tae Kim  ;  Seong Yong Park  ;  Chang Young Lee  ;  Jin Gu Lee  ;  Dae Joon Kim  ;  Hyo Chae Paik 
Citation
 Journal of Chest Surgery, Vol.55(2) : 126-142, 2022-04 
Journal Title
Journal of Chest Surgery
ISSN
 2765-1606 
Issue Date
2022-04
Keywords
Thymectomy ; Thymic epithelial tumor ; Video-assisted thoracic surgery
Abstract
Background: Thymic epithelial tumors (TETs) are rare, and information regarding their surgical outcomes and prognostic factors has rapidly changed in the past few decades. We analyzed surgical treatment practices for TETs and outcomes in terms of overall survival (OS) and freedom from recurrence (FFR) during a 13-year period in Korea.

Methods: In total, 1,298 patients with surgically resected TETs between 2000 and 2013 were enrolled retrospectively. OS and FFR were calculated using the Kaplan-Meier method and evaluated with the log-rank test. Prognostic factors for OS and FFR were analyzed with multivariable Cox regression.

Results: A total of 1,098 patients were diagnosed with thymoma, and 200 patients were diagnosed with thymic carcinoma. Over the study period, the total number of patients with surgically treated TETs and the proportion of patients who underwent minimally invasive thymic surgery (MITS) increased annually. The 5-year and 10-year survival rates of surgically treated TETs were 91.0% and 82.1%, respectively. The 5-year and 10-year recurrence rates were 86.3% and 80.0%, respectively. The outcomes of surgically treated TETs improved over time. Multivariable Cox hazards analysis for OS, age, tumor size, and Masaoka-Koga stage were independent predictors of prognosis. The World Health Organization classification and tumor-node-metastasis (TNM) staging were also related to the prognosis of TETs.

Conclusion: Surgical treatment of TETs achieved a good prognosis with a recent increase in MITS. The M-K stage was the most important prognostic factor for OS and FFR. The new TNM stage could also be an effective predictor of the outcomes of TETs.
Files in This Item:
T202205480.pdf Download
DOI
10.5090/jcs.21.124
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Park, Seong Yong(박성용) ORCID logo https://orcid.org/0000-0002-5180-3853
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191324
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