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Association between Body Mass Index and Chronic Kidney Disease in Asian Populations: A Participant-level Meta-Analysis

Authors
 Bjorn Kaijun Betzler  ;  Rehena Sultana  ;  Riswana Banu  ;  Yih Chung Tham  ;  Cynthia Ciwei Lim  ;  Ya Xing Wang  ;  Vinay Nangia  ;  E Shyong Tai  ;  Tyler Hyungtaek Rim  ;  Mukharram M Bikbov  ;  Jost B Jonas  ;  Ching-Yu Cheng  ;  Charumathi Sabanayagam 
Citation
 MATURITAS, Vol.154 : 46-54, 2021-12 
Journal Title
MATURITAS
ISSN
 0378-5122 
Issue Date
2021-12
MeSH
Adult ; Aged ; Asians / statistics & numerical data* ; Body Mass Index* ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Obesity / complications ; Obesity / epidemiology ; Overweight / complications* ; Overweight / epidemiology ; Renal Insufficiency, Chronic / ethnology* ; Renal Insufficiency, Chronic / etiology ; Risk Factors
Keywords
Asian ; Body Mass Index ; Chronic kidney disease ; Obesity
Abstract
Obesity and chronic kidney disease (CKD) are major public health problems worldwide. However, the association between body mass index (BMI) and CKD is inconclusive in Asians. In this meta-analysis, eight population-based studies, from China, India, Russia (Asian), Singapore and South Korea, provided individual-level data (n=50037). CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. BMI was analyzed both as a continuous variable and in three categories: <25kg/m2, normal; 25-29.9kg/m2, overweight; and ≥30kg/m2, obese. The association between BMI and CKD was evaluated in each study using multivariable logistic regression models and individual estimates were pooled using random-effect meta-analysis to obtain the pooled odds ratio (OR) and 95% confidence interval (CI). Associations were also evaluated in subgroups of age, gender, smoking, diabetes, and hypertension status. Of 50037 adults, 4258 (8.5%) had CKD. 13328 (26.6%) individuals were overweight while 4440 (8.9%) were obese. The prevalence of any CKD ranged from 3.5% to 29.1% across studies. In pooled analysis, both overweight and obesity were associated with increased odds of CKD, with pooled OR (95% CI) of 1.15 (1.03-1.29) and 1.23 (1.06-1.42), respectively. In subgroup analyses, significant associations between BMI and CKD were observed in adult males, non-smokers, and those with diabetes and arterial hypertension (all p<0.05). When evaluated as a continuous variable, BMI was not significantly associated with CKD. If confirmed in longitudinal studies, these results may have clinical implications in risk stratification and preventive measures, given that obesity and CKD are two major chronic diseases with substantial public health burden worldwide.
Full Text
https://www.sciencedirect.com/science/article/pii/S037851222100267X
DOI
10.1016/j.maturitas.2021.09.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Rim, Tyler Hyungtaek(임형택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191109
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