Cited 9 times in
Roots of Lithospermum erythrorhizon promotes retinal cell survival in optic nerve crush-induced retinal degeneration
DC Field | Value | Language |
---|---|---|
dc.date.accessioned | 2022-11-24T00:50:55Z | - |
dc.date.available | 2022-11-24T00:50:55Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0014-4835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191033 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0014483520306771 | - |
dc.description.abstract | Lithospermum erythrorhizon (L. erythrorhizon), used in traditional medicine, is a potent wound healing, anti-inflammatory and antioxidant plant. However, the effects of L. erythrorhizon on retinal degenerative diseases remain unknown. Here, we explored the protective effects of L. erythrorhizon in in vitro and in vivo retinal degeneration. We found that ethanol extract of L. erythrorhizon (EELE) and the dichloromethane fraction of L. erythrorhizon (MCLE) significantly increased cell viability under glutamate/BSO-induced excitotoxicity/oxidative stress in R28 cells. Treatment with EELE and MCLE reduced the intracellular reactive oxygen species (ROS) and the levels of apoptotic proteins, such as cleaved PARP and cleaved caspase-3. Furthermore, oral administration of EELE and MCLE in an in vivo optic nerve crush mouse model decreased RGC cell death and increased retinal thickness. The major compound between EELE and MCLE was found to be lithospermic acid A (LAA), which has been shown to prevent the elevation of ROS in R28. Therefore, EELE and MCLE have protective effects against the death of retinal cells in vitro and in vivo, and the major compound, LAA, has an antioxidant effect on retinal cells, suggesting that EELE and MCLE could be beneficial agents for retinal degenerative diseases, including glaucoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.relation.isPartOf | EXPERIMENTAL EYE RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis Regulatory Proteins / metabolism | - |
dc.subject.MESH | Benzofurans / pharmacology | - |
dc.subject.MESH | Cell Culture Techniques | - |
dc.subject.MESH | Cell Survival / drug effects | - |
dc.subject.MESH | Chromatography, High Pressure Liquid | - |
dc.subject.MESH | Depsides / pharmacology | - |
dc.subject.MESH | Electrophoresis, Polyacrylamide Gel | - |
dc.subject.MESH | Lithospermum / chemistry* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Nerve Crush | - |
dc.subject.MESH | Optic Nerve Injuries / drug therapy* | - |
dc.subject.MESH | Optic Nerve Injuries / metabolism | - |
dc.subject.MESH | Oxidative Stress / drug effects | - |
dc.subject.MESH | Phytotherapy / methods* | - |
dc.subject.MESH | Plant Extracts / therapeutic use* | - |
dc.subject.MESH | Plant Roots / chemistry* | - |
dc.subject.MESH | Reactive Oxygen Species / metabolism | - |
dc.subject.MESH | Retinal Degeneration / drug therapy* | - |
dc.subject.MESH | Retinal Degeneration / metabolism | - |
dc.subject.MESH | Retinal Ganglion Cells / drug effects* | - |
dc.subject.MESH | Retinal Ganglion Cells / metabolism | - |
dc.subject.MESH | Tomography, Optical Coherence | - |
dc.title | Roots of Lithospermum erythrorhizon promotes retinal cell survival in optic nerve crush-induced retinal degeneration | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Tae Kyeom Kang | - |
dc.contributor.googleauthor | Tam Thi Le | - |
dc.contributor.googleauthor | Kyung-A Kim | - |
dc.contributor.googleauthor | Young-Joo Kim | - |
dc.contributor.googleauthor | Wook-Bin Lee | - |
dc.contributor.googleauthor | Sang Hoon Jung | - |
dc.identifier.doi | 10.1016/j.exer.2020.108419 | - |
dc.relation.journalcode | J00868 | - |
dc.identifier.eissn | 1096-0007 | - |
dc.identifier.pmid | 33383026 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Glaucoma | - |
dc.subject.keyword | Lithospermum erythrorhizon | - |
dc.subject.keyword | Optic nerve crush | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Retinal degeneration | - |
dc.citation.volume | 203 | - |
dc.citation.startPage | 108419 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL EYE RESEARCH, Vol.203 : 108419, 2021-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.