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Obesity measures at baseline, their trajectories over time, and the incidence of chronic kidney disease: A 14 year cohort study among Korean adults

Authors
 Hyun-Soo Zhang  ;  Seokyung An  ;  Choonghyun Ahn  ;  Sue K Park  ;  Boyoung Park 
Citation
 NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol.31(3) : 782-792, 2021-03 
Journal Title
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
ISSN
 0939-4753 
Issue Date
2021-03
MeSH
Adult ; Aged ; Anthropometry* ; Body Mass Index ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Obesity / diagnosis* ; Obesity / epidemiology ; Predictive Value of Tests ; Renal Insufficiency, Chronic / diagnosis ; Renal Insufficiency, Chronic / epidemiology* ; Republic of Korea / epidemiology ; Risk Assessment ; Risk Factors ; Time Factors ; Waist Circumference ; Waist-Height Ratio
Keywords
Body mass index ; Chronic kidney disease ; Hip circumference ; Waist circumference ; Waist-hip ratio
Abstract
Background and aims: We investigated the association of baseline obesity measures, i.e. body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR), and their trajectories over time with incident chronic kidney disease (CKD).

Methods and results: Utilizing data from 2001 to 2014 for 9796 Korean adults without CKD at baseline, the association of baseline obesity measures with incident CKD was evaluated using logistic regression. Further, among 5605 subjects with repeated measures, the effect of the trajectories in obesity measures on CKD incidence was investigated via Cox regression. Baseline obesity in terms of BMI, WC, and HC increased the odds of incident CKD (odds ratio (OR) 1.19, 95% confidence interval (CI) 1.05-1.33; OR 1.22, 95% CI 1.07-1.38; and OR 1.25, 95% CI 1.11-1.41, respectively), while baseline WHR did not show such an association. A "became non-obese" BMI, WC, or WHR trajectory, and a "constantly not large" HC trajectory decreased the hazard of incident CKD (hazard ratio (HR) 0.70, 95% CI 0.50-0.99; HR 0.61, 95% CI 0.40-0.92; HR 0.55, 95% CI 0.35-0.85; and HR 0.81, 95% CI 0.69-0.95, respectively) when compared with a "constantly obese or became obese" trajectory.

Conclusion: Both baseline obesity and obesity trajectories over time were associated with CKD incidence. BMI and WC were equally good measures of CKD risk, while WHR was not. Separately examining WC and HC components of WHR (= WC/HC) may explain WHR's inconsistency, and WHR's usefulness as a measure of CKD risk should be reevaluated.
Full Text
https://www.sciencedirect.com/science/article/pii/S0939475320304762
DOI
10.1016/j.numecd.2020.10.021
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191020
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