0 64

Cited 0 times in

Implication of Small Vessel Disease MRI Markers in Alzheimer's Disease and Lewy Body Disease

Authors
 Mincheol Park  ;  Kyoungwon Baik  ;  Young-Gun Lee  ;  Sung Woo Kang  ;  Jin Ho Jung  ;  Seong Ho Jeong  ;  Phil Hyu Lee  ;  Young H Sohn  ;  Byoung Seok Ye 
Citation
 JOURNAL OF ALZHEIMERS DISEASE, Vol.83(2) : 545-556, 2021-09 
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
 1387-2877 
Issue Date
2021-09
MeSH
Aged ; Alzheimer Disease / complications* ; Attention / physiology ; Biomarkers / blood* ; Brain / pathology ; Cognitive Dysfunction / diagnostic imaging ; Cognitive Dysfunction / etiology ; Female ; Humans ; Lewy Body Disease / complications* ; Magnetic Resonance Imaging* ; Male ; Neuropsychological Tests ; Positron-Emission Tomography ; White Matter / pathology*
Keywords
Alzheimer’s disease ; Lewy body disease ; mixed disease ; periventricular white matter hyperintensity ; small vessel disease ; white matter hyperintensity
Abstract
Background: Small vessel disease (SVD) magnetic resonance imaging (MRI) markers including deep and periventricular white matter hyperintensities (PWMH), lacunes, and microbleeds are frequently observed in Alzheimer's disease (AD) and Lewy body disease (LBD), but their implication has not been clearly elucidated.

Objective: To investigate the implication of SVD MRI markers in cognitively impaired patients with AD and/or LBD.

Methods: We consecutively recruited 57 patients with pure AD-related cognitive impairment (ADCI), 49 with pure LBD-related cognitive impairment (LBCI), 45 with mixed ADCI/LBCI, and 34 controls. All participants underwent neuropsychological tests, brain MRI, and amyloid positron emission tomography. SVD MRI markers including the severity of deep and PWMH and the number of lacunes and microbleeds were visually rated. The relationships among vascular risk factors, SVD MRI markers, ADCI, LBCI, and cognitive scores were investigated after controlling for appropriate covariates.

Results: LBCI was associated with more severe PWMH, which was conversely associated with an increased risk of LBCI independently of vascular risk factors and ADCI. PWMH was associated with attention and visuospatial dysfunction independently of vascular risk factors, ADCI, and LBCI. Both ADCI and LBCI were associated with more lobar microbleeds, but not with deep microbleeds.

Conclusion: Our findings suggest that PWMH could reflect degenerative process related with LBD, and both AD and LBD independently increase lobar microbleeds.
Full Text
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210669
DOI
10.3233/JAD-210669
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sung Woo(강성우)
Park, Mincheol(박민철)
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Young-Gun(이영건)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Jung, Jin Ho(정진호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190770
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links