Cited 3 times in
Implication of Small Vessel Disease MRI Markers in Alzheimer's Disease and Lewy Body Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박민철 | - |
dc.contributor.author | 백경원 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 예병석 | - |
dc.contributor.author | 이영건 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정진호 | - |
dc.contributor.author | 강성우 | - |
dc.date.accessioned | 2022-11-24T00:33:12Z | - |
dc.date.available | 2022-11-24T00:33:12Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190770 | - |
dc.description.abstract | Background: Small vessel disease (SVD) magnetic resonance imaging (MRI) markers including deep and periventricular white matter hyperintensities (PWMH), lacunes, and microbleeds are frequently observed in Alzheimer's disease (AD) and Lewy body disease (LBD), but their implication has not been clearly elucidated. Objective: To investigate the implication of SVD MRI markers in cognitively impaired patients with AD and/or LBD. Methods: We consecutively recruited 57 patients with pure AD-related cognitive impairment (ADCI), 49 with pure LBD-related cognitive impairment (LBCI), 45 with mixed ADCI/LBCI, and 34 controls. All participants underwent neuropsychological tests, brain MRI, and amyloid positron emission tomography. SVD MRI markers including the severity of deep and PWMH and the number of lacunes and microbleeds were visually rated. The relationships among vascular risk factors, SVD MRI markers, ADCI, LBCI, and cognitive scores were investigated after controlling for appropriate covariates. Results: LBCI was associated with more severe PWMH, which was conversely associated with an increased risk of LBCI independently of vascular risk factors and ADCI. PWMH was associated with attention and visuospatial dysfunction independently of vascular risk factors, ADCI, and LBCI. Both ADCI and LBCI were associated with more lobar microbleeds, but not with deep microbleeds. Conclusion: Our findings suggest that PWMH could reflect degenerative process related with LBD, and both AD and LBD independently increase lobar microbleeds. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOS Press | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Alzheimer Disease / complications* | - |
dc.subject.MESH | Attention / physiology | - |
dc.subject.MESH | Biomarkers / blood* | - |
dc.subject.MESH | Brain / pathology | - |
dc.subject.MESH | Cognitive Dysfunction / diagnostic imaging | - |
dc.subject.MESH | Cognitive Dysfunction / etiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lewy Body Disease / complications* | - |
dc.subject.MESH | Magnetic Resonance Imaging* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | White Matter / pathology* | - |
dc.title | Implication of Small Vessel Disease MRI Markers in Alzheimer's Disease and Lewy Body Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Mincheol Park | - |
dc.contributor.googleauthor | Kyoungwon Baik | - |
dc.contributor.googleauthor | Young-Gun Lee | - |
dc.contributor.googleauthor | Sung Woo Kang | - |
dc.contributor.googleauthor | Jin Ho Jung | - |
dc.contributor.googleauthor | Seong Ho Jeong | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Byoung Seok Ye | - |
dc.identifier.doi | 10.3233/JAD-210669 | - |
dc.contributor.localId | A06165 | - |
dc.contributor.localId | A05133 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A04603 | - |
dc.contributor.localId | A06069 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A05998 | - |
dc.contributor.localId | A06311 | - |
dc.relation.journalcode | J01231 | - |
dc.identifier.eissn | 1875-8908 | - |
dc.identifier.pmid | 34366356 | - |
dc.identifier.url | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210669 | - |
dc.subject.keyword | Alzheimer’s disease | - |
dc.subject.keyword | Lewy body disease | - |
dc.subject.keyword | mixed disease | - |
dc.subject.keyword | periventricular white matter hyperintensity | - |
dc.subject.keyword | small vessel disease | - |
dc.subject.keyword | white matter hyperintensity | - |
dc.contributor.affiliatedAuthor | 박민철 | - |
dc.contributor.affiliatedAuthor | 백경원 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 예병석 | - |
dc.contributor.affiliatedAuthor | 이영건 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정진호 | - |
dc.contributor.affiliatedAuthor | 강성우 | - |
dc.citation.volume | 83 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 545 | - |
dc.citation.endPage | 556 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, Vol.83(2) : 545-556, 2021-09 | - |
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