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Fatigue is associated with depression independent of excessive daytime sleepiness in the general population

Authors
 Jun-Sang Sunwoo  ;  Daeyoung Kim  ;  Min Kyung Chu  ;  Chang-Ho Yun  ;  Kwang Ik Yang 
Citation
 SLEEP AND BREATHING, Vol.26(2) : 933-940, 2022-06 
Journal Title
SLEEP AND BREATHING
ISSN
 1520-9512 
Issue Date
2022-06
MeSH
Adult ; Cross-Sectional Studies ; Depression / complications ; Depression / diagnosis ; Depression / epidemiology ; Disorders of Excessive Somnolence* / complications ; Disorders of Excessive Somnolence* / diagnosis ; Disorders of Excessive Somnolence* / epidemiology ; Fatigue / complications ; Fatigue / epidemiology ; Female ; Humans ; Male ; Middle Aged ; Sleep ; Sleep Wake Disorders* / complications
Keywords
Depression ; Fatigue ; Sleep duration ; Sleepiness
Abstract
Purpose: This study aimed to investigate sleep problems and comorbid conditions associated with fatigue in the general population.

Methods: The data were obtained from a nationwide cross-sectional survey conducted in 2018. The Fatigue Severity Scale was used to assess fatigue. We examined sleep habits, such as workday sleep duration, chronotype, and free-day catch-up sleep, excessive daytime sleepiness (EDS), depression, and other comorbid conditions. We conducted multiple logistic regression analysis with the presence of fatigue as a dependent variable.

Results: Of 2,493 adults aged 19 to 92 years, 50% men, mean age was 47.9 ± 16.4 years. The average workday sleep duration was 7.1 ± 1.1 h, and the prevalence of fatigue was 31%. After adjusting for potential confounders, fatigue was associated with EDS (odds ratio [OR] 3.751, 95% confidence interval [CI] 2.928-4.805), depression (OR 3.736, 95% CI 2.701-5.169), perceived insufficient sleep (OR 1.516, 95% CI 1.249-1.839), free-day catch-up sleep (OR 1.123, 95% CI 1.020-1.235), less alcohol intake (OR 0.570, 95% CI 0.432-0.752), and physical inactivity (OR 0.737, 95% CI 0.573-0.948). On subgroup analysis, fatigue was additionally associated with short workday sleep duration (OR 0.899, 95% CI 0.810-0.997) in individuals without EDS. However, among those with EDS, only depression (OR 2.842, 95% CI 1.511-5.343) and less alcohol intake (OR 0.476, 95% CI 0.247-0.915) were associated with fatigue.

Conclusion: Fatigue was significantly associated with depression independent of EDS. Further research is warranted to better understand the pathophysiological relationship between fatigue, depression, and sleep.
Full Text
https://link.springer.com/article/10.1007/s11325-021-02448-3
DOI
10.1007/s11325-021-02448-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yun Joong(김윤중) ORCID logo https://orcid.org/0000-0002-2956-1552
Chu, Min Kyung(주민경) ORCID logo https://orcid.org/0000-0001-6221-1346
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190684
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