Taste or gustation is a critical sensory system for animal survival, guiding animals toward beneficial food sources and helping them avoid harmful ones. Many aspects of gustatory systems have been evolutionarily conserved, making it possible to investigate them by genetic model organisms. Due to the ease of its genetic manipulation and the richness of its genetic toolkit, the nature of peripheral taste coding is best understood in the model organism Drosophila melanogaster. In this review, we summarize our groups achievements over the past two decades and introduce some current perspectives on the fruit fly gustatory receptors (Grs).