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1980–2019년 기간 동안 소아청소년 알레르기질환에서 항원 감작의 변화

Authors
 정재화  ;  김가은  ;  박미르  ;  김수연  ;  김민정  ;  이용주  ;  김윤희  ;  김경원  ;  손명현 
Citation
 ALLERGY ASTHMA & RESPIRATORY DISEASE, Vol.9(4) : 208-215, 2021-10 
Journal Title
ALLERGY ASTHMA & RESPIRATORY DISEASE
ISSN
 2288-0402 
Issue Date
2021-10
Keywords
Child ; Allergens ; Sensitization ; Change
Abstract
Purpose
Allergen sensitization is constantly changing, and understanding these changes can help manage and prevent allergic diseases. This research analyzed and compared the changes in allergen sensitization in children diagnosed with allergic diseases using the skin test and the multiple allergen simultaneous test.

Methods
We retrospectively analyzed the data on children who were diagnosed with allergic diseases and received immunotherapy at Yonsei Medical Center from 1980 to 1998 and they were screened for allergen sensitization at Severance Hospital from 2005 to 2019.

Results
Between 1980 and 1998, and between 2005 and 2019, data on 3,205 (male, 70.3%; mean age, 7.2±2.9 years) and 15,318 children (male, 62.8%; mean age, 8.8±4.5 years) were analyzed. The sensitized allergens that appeared in the 1980–1998 included Dermatophagoides farinae (91.0%), Dermatophagoides pteronyssinus (76.3%), cockroach (13.5%), and Alternaria (11.5%), in order of frequency; further, the sensitized allergens that appeared in the 2005–2019 included D. farinae (45.0%), D. pteronyssinus (39.6%), cat dander (12.2%), and dog dander (9.1%), in order of frequency. D. farinae and D. pteronyssinus demonstrated the highest sensitization rates, although the rates decreased gradually. The sensitization to cat dander and dog dander showed a growing trend, and sensitization to Humulus japonicus, Candida, and cockroach decreased after 2005.

Conclusion
Over the past 40 years, the allergen sensitization in Korean children with allergic diseases has increased. These changes reflect lifestyle and environmental changes and influence allergic disease management approaches. Thus, changes in allergic sensitization should be monitored continuously.
Files in This Item:
T202126164.pdf Download
DOI
10.4168/aard.2021.9.4.208
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0002-5634-9709
Kim, Soo Yeon(김수연) ORCID logo https://orcid.org/0000-0003-4965-6193
Kim, Yoon Hee(김윤희) ORCID logo https://orcid.org/0000-0002-2149-8501
Park, Mireu(박미르)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Lee, Yong Ju(이용주) ORCID logo https://orcid.org/0000-0002-0796-2558
Jung, Jae Hwa(정재화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190554
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