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The substantial loss of H3K27me3 can stratify risk in grade 2, but not in grade 3 meningioma

Authors
 Minsun Jung  ;  Seong-Ik Kim  ;  Ka Young Lim  ;  Jeongmo Bae  ;  Chul-Kee Park  ;  Seung Hong Choi  ;  Sung-Hye Park  ;  Jae-Kyung Won 
Citation
 HUMAN PATHOLOGY, Vol.115 : 96-103, 2021-09 
Journal Title
HUMAN PATHOLOGY
ISSN
 0046-8177 
Issue Date
2021-09
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor / genetics ; DNA Methylation / genetics* ; Female ; Histones / genetics* ; Humans ; Male ; Meningeal Neoplasms / genetics ; Meningeal Neoplasms / pathology* ; Meningioma / genetics ; Meningioma / pathology* ; Middle Aged ; Neoplasm Grading ; Prognosis ; Young Adult
Keywords
H3K27 trimethylation ; Immunohistochemistry ; Meningioma ; Neoplasm grading ; Prognosis
Abstract
Trimethylation of lysine 27 of histone H3 (H3K27me3) has recently emerged as a crucial epigenetic marker in meningioma. The loss of H3K27me3 expression might predict the early recurrence of grade 1 and 2 meningiomas. However, this is controversial in terms of grade 3 meningioma and the effects of H3K27me3 on the overall survival (OS) of patients with low low-grade meningioma have not been studied. Therefore, we immunohistochemically assessed the prognostic implications of H3K27me3 expression in grade 2 and 3 meningiomas. Whole-slide H3K27me3 immunostaining was evaluated for strict quality control and to confirm a significant correlation (P < .0001) with tissue microarray results. The effects of tissue age on H3K27me3 immunostaining were also evaluated, to select an appropriate cohort for survival analysis. Log-rank tests of 115 grade 2 meningiomas and 26 grade 3 meningiomas showed that the loss of H3K27me3 expression was a prognostic factor for early recurrence (P < .0001) and death (P = .00012) in grade 2, but not in grade 3 meningioma. Multivariate analysis revealed that age, recurrent tumor, and loss of H3K27me3 expression (hazard ratio, 1.264-7.510; P = .0133) were significant for recurrentrecurrence-free survival (RFS), and that recurrent tumor and loss of H3K27me3 expression (hazard ratio, 1.717-120.621; P = .0140) were significant for OS. We concluded that H3K27me3 expression is a significant prognostic factor for the RFS and OS of patients with grade 2 meningioma; it should be considered as an ancillary test for risk stratification of this meningioma.
Full Text
https://www.sciencedirect.com/science/article/pii/S004681772100112X
DOI
10.1016/j.humpath.2021.06.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Jung, Minsun(정민선) ORCID logo https://orcid.org/0000-0002-8701-4282
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190493
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