Cited 14 times in
The substantial loss of H3K27me3 can stratify risk in grade 2, but not in grade 3 meningioma
DC Field | Value | Language |
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dc.contributor.author | 정민선 | - |
dc.date.accessioned | 2022-09-14T01:31:13Z | - |
dc.date.available | 2022-09-14T01:31:13Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190493 | - |
dc.description.abstract | Trimethylation of lysine 27 of histone H3 (H3K27me3) has recently emerged as a crucial epigenetic marker in meningioma. The loss of H3K27me3 expression might predict the early recurrence of grade 1 and 2 meningiomas. However, this is controversial in terms of grade 3 meningioma and the effects of H3K27me3 on the overall survival (OS) of patients with low low-grade meningioma have not been studied. Therefore, we immunohistochemically assessed the prognostic implications of H3K27me3 expression in grade 2 and 3 meningiomas. Whole-slide H3K27me3 immunostaining was evaluated for strict quality control and to confirm a significant correlation (P < .0001) with tissue microarray results. The effects of tissue age on H3K27me3 immunostaining were also evaluated, to select an appropriate cohort for survival analysis. Log-rank tests of 115 grade 2 meningiomas and 26 grade 3 meningiomas showed that the loss of H3K27me3 expression was a prognostic factor for early recurrence (P < .0001) and death (P = .00012) in grade 2, but not in grade 3 meningioma. Multivariate analysis revealed that age, recurrent tumor, and loss of H3K27me3 expression (hazard ratio, 1.264-7.510; P = .0133) were significant for recurrentrecurrence-free survival (RFS), and that recurrent tumor and loss of H3K27me3 expression (hazard ratio, 1.717-120.621; P = .0140) were significant for OS. We concluded that H3K27me3 expression is a significant prognostic factor for the RFS and OS of patients with grade 2 meningioma; it should be considered as an ancillary test for risk stratification of this meningioma. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | W B Saunders | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor / genetics | - |
dc.subject.MESH | DNA Methylation / genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Histones / genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Meningeal Neoplasms / genetics | - |
dc.subject.MESH | Meningeal Neoplasms / pathology* | - |
dc.subject.MESH | Meningioma / genetics | - |
dc.subject.MESH | Meningioma / pathology* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Young Adult | - |
dc.title | The substantial loss of H3K27me3 can stratify risk in grade 2, but not in grade 3 meningioma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Minsun Jung | - |
dc.contributor.googleauthor | Seong-Ik Kim | - |
dc.contributor.googleauthor | Ka Young Lim | - |
dc.contributor.googleauthor | Jeongmo Bae | - |
dc.contributor.googleauthor | Chul-Kee Park | - |
dc.contributor.googleauthor | Seung Hong Choi | - |
dc.contributor.googleauthor | Sung-Hye Park | - |
dc.contributor.googleauthor | Jae-Kyung Won | - |
dc.identifier.doi | 10.1016/j.humpath.2021.06.005 | - |
dc.contributor.localId | A06280 | - |
dc.relation.journalcode | J01011 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.identifier.pmid | 34186055 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S004681772100112X | - |
dc.subject.keyword | H3K27 trimethylation | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Meningioma | - |
dc.subject.keyword | Neoplasm grading | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Jung, Minsun | - |
dc.contributor.affiliatedAuthor | 정민선 | - |
dc.citation.volume | 115 | - |
dc.citation.startPage | 96 | - |
dc.citation.endPage | 103 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, Vol.115 : 96-103, 2021-09 | - |
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