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Lactoferrin-Anchored Tannylated Mesoporous Silica Nanomaterials for Enhanced Osteo-Differentiation Ability

Authors
 Sung Hyun Noh  ;  Han-Saem Jo  ;  Somang Choi  ;  Hee Gyeong Song  ;  Hak-Jun Kim  ;  Keung Nyun Kim  ;  Sung Eun Kim  ;  Kyeongsoon Park 
Citation
 PHARMACEUTICS, Vol.13(1) : 30, 2021-01 
Journal Title
PHARMACEUTICS
Issue Date
2021-01
Keywords
adipose-derived stem cells ; lactoferrin ; mesoporous silica nanomaterials ; osteo-differentiation ability
Abstract
In the present study, we created lactoferrin-anchored mesoporous silica nanomaterials with absorbed tannic acid (LF/TA-MSNs) and evaluated the effect of these LF/TA-MSNs on the in vitro osteo-differentiation ability of adipose-derived stem cells (ADSCs) by testing alkaline phosphatase (ALP) level, calcium accumulation, and expression of osteo-differentiation-specific genes, including osteocalcin (OCN) and osteopontin (OPN). Both bare MSNs and LF/TA-MSNs exhibited round nano-particle structures. The LF/TA-MSNs demonstrated prolonged LF release for up to 28 days. Treatment of ADSCs with LF (50 μg)/TA-MSNs resulted in markedly higher ALP level and calcium accumulation compared to treatment with LF (10 μg)/TA-MSNs or bare MSNs. Furthermore, LF (50 μg)/TA-MSNs remarkably increased mRNA levels of osteo-differentiation-specific genes, including OCN and OPN, compared to MSNs or LF (10 μg)/TA-MSNs. Together, these data suggest that the ability of LF/TA-MSNs to enhance osteo-differentiation of ADSCs make them a possible nanovehicle for bone healing and bone regeneration in patients with bone defect or disease.
Files in This Item:
T202125974.pdf Download
DOI
10.3390/pharmaceutics13010030
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keung Nyun(김긍년)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190329
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