Cited 8 times in
Lactoferrin-Anchored Tannylated Mesoporous Silica Nanomaterials for Enhanced Osteo-Differentiation Ability
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김긍년 | - |
dc.date.accessioned | 2022-09-14T01:11:19Z | - |
dc.date.available | 2022-09-14T01:11:19Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190329 | - |
dc.description.abstract | In the present study, we created lactoferrin-anchored mesoporous silica nanomaterials with absorbed tannic acid (LF/TA-MSNs) and evaluated the effect of these LF/TA-MSNs on the in vitro osteo-differentiation ability of adipose-derived stem cells (ADSCs) by testing alkaline phosphatase (ALP) level, calcium accumulation, and expression of osteo-differentiation-specific genes, including osteocalcin (OCN) and osteopontin (OPN). Both bare MSNs and LF/TA-MSNs exhibited round nano-particle structures. The LF/TA-MSNs demonstrated prolonged LF release for up to 28 days. Treatment of ADSCs with LF (50 μg)/TA-MSNs resulted in markedly higher ALP level and calcium accumulation compared to treatment with LF (10 μg)/TA-MSNs or bare MSNs. Furthermore, LF (50 μg)/TA-MSNs remarkably increased mRNA levels of osteo-differentiation-specific genes, including OCN and OPN, compared to MSNs or LF (10 μg)/TA-MSNs. Together, these data suggest that the ability of LF/TA-MSNs to enhance osteo-differentiation of ADSCs make them a possible nanovehicle for bone healing and bone regeneration in patients with bone defect or disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | PHARMACEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Lactoferrin-Anchored Tannylated Mesoporous Silica Nanomaterials for Enhanced Osteo-Differentiation Ability | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Sung Hyun Noh | - |
dc.contributor.googleauthor | Han-Saem Jo | - |
dc.contributor.googleauthor | Somang Choi | - |
dc.contributor.googleauthor | Hee Gyeong Song | - |
dc.contributor.googleauthor | Hak-Jun Kim | - |
dc.contributor.googleauthor | Keung Nyun Kim | - |
dc.contributor.googleauthor | Sung Eun Kim | - |
dc.contributor.googleauthor | Kyeongsoon Park | - |
dc.identifier.doi | 10.3390/pharmaceutics13010030 | - |
dc.contributor.localId | A00331 | - |
dc.relation.journalcode | J02504 | - |
dc.identifier.eissn | 1999-4923 | - |
dc.identifier.pmid | 33375294 | - |
dc.subject.keyword | adipose-derived stem cells | - |
dc.subject.keyword | lactoferrin | - |
dc.subject.keyword | mesoporous silica nanomaterials | - |
dc.subject.keyword | osteo-differentiation ability | - |
dc.contributor.alternativeName | Kim, Keung Nyun | - |
dc.contributor.affiliatedAuthor | 김긍년 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 30 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, Vol.13(1) : 30, 2021-01 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.